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Article
Antioxidant and Anticancer Activities of Wampee (Clausena lansium (Lour.) Skeels) Peel
Journal of Biomedicine and Biotechnology
  • K. Nagendra Prasad, Chinese Academy of Sciences
  • Jing Hao, Chinese Academy of Sciences
  • Chun Yi, Chinese Academy of Sciences
  • Dandan Zhang, Chinese Academy of Sciences
  • Shengxiang Qiu, Chinese Academy of Sciences
  • Yueming Jiang, Chinese Academy of Sciences
  • Mingwei Zhang, Guangdong Academy of Agricultural Sciences
  • Feng Chen, Clemson University
Document Type
Article
Publication Date
1-1-2009
Publisher
Hindawi Publishing
Disciplines
Abstract
Antioxidant activities of wampee peel extracts using five different solvents (ethanol, hexane, ethyl acetate, butanol and water) were determined by using in-vitro antioxidant models including total antioxidant capability, 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity, reducing power, and superoxide scavenging activity. Ethyl acetate fraction (EAF) exhibited the highest antioxidant activity compared to other fractions, even higher than synthetic antioxidant butylated hydroxyl toluene (BHT). In addition, the EAF exhibited strong anticancer activities against human gastric carcinoma (SGC-7901), human hepatocellular liver carcinoma (HepG-2) and human lung adenocarcinoma (A-549) cancer cell lines, higher than cisplatin, a conventional anticancer drug. The total phenolic content of wampee fraction was positively correlated with the antioxidant activity. This is the first report on the antioxidant and anticancer activities of the wampee peel extract. Thus, wampee peel can be used potentially as a readily accessible source of natural antioxidants and a possible pharmaceutical supplement.
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This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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