© 2019 IEEE. Lung cancer leads deaths caused by cancer for both men and women worldwide, that is why creating systems for early diagnosis with machine learning algorithms and nominal user intervention is of huge importance. In this manuscript, a new system for lung nodule diagnosis, using features extracted from one computed tomography (CT) scan, is presented. This system integrates global and local features to give an implication of the nodule prior growth rate, which is the main point for diagnosis of pulmonary nodules. 3D adjustable local binary pattern and some basic geometric features are used to extract the nodule global features, and the local features are extracted using 3D convolutional neural networks (3D-CNN) because of its ability to exploit the spatial correlation of input data in an efficient way. Finally all these features are integrated using autoencoder to give a final diagnosis for the lung nodule whether benign or malignant. The system was evaluated using 727 nodules extracted from the Lung Image Database Consortium (LIDC) dataset. The proposed system diagnosis accuracy, sensitivity, and specificity were 92.20%,93.55%, and 91.20% respectively. The proposed framework demonstrated its promise as a valuable tool for lung cancer detection evidenced by its higher accuracy.