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Cytokine expression and microglial activation in progressive supranuclear palsy.
Parkinsonism & Related Disorders (2011)
  • Rafael Fernández-Botrán, University of Louisville
  • Zeshan Ahmed, University College London
  • Fabian Crespo, University of Louisville
  • Chandler Gatenbee, University of Louisville
  • John Gonzalez, Mayo Clinic
  • Dennis W. Dickson, Mayo Clinic
  • Irene Litvan, University of Louisville
Abstract
Although little is known about the etiology of progressive supranuclear palsy (PSP), genetic and epigenetic factors, oxidative injury and inflammation are thought to contribute to its development and/or progression. Evidence for activated glia involvement in PSP has raised the possibility that neuroinflammation may contribute to its pathogenesis. To investigate the correlation between neuroinflammation and PSP, a comparative study was conducted on the patterns of cytokine expression in different regions of the brains of PSP, Alzheimer’s disease (AD) patients and normal controls. Our results show different patterns of cytokine expression in each disease, with the expression of IL-1β transcripts being significantly higher in the substantia nigra of PSP than in AD and controls, while AD brains had significantly higher IL-1β expression in the parietal cortex compared to PSP and controls. In addition, expression of TGFβ was significantly higher in the cortical areas (particularly frontal and parietal lobes) of AD compared to PSP and controls. These results show a disease-specific topographical relationship among the expression of certain cytokines (IL-1β and TGFβ), microglial activation and neurodegenerative changes, suggesting that these cytokines may contribute to the pathologic process. If so, the use of cytokine-inhibitors and/or other anti-inflammatory agents may be able to slow disease progression in PSP.
Keywords
  • Alzheimer’s disease,
  • Brain,
  • Cytokines,
  • Inflammation,
  • Microglia,
  • Progressive supranuclear palsy
Publication Date
November, 2011
DOI
10.1016/j.parkreldis.2011.06.007
Citation Information
Rafael Fernández-Botrán, Zeshan Ahmed, Fabian Crespo, Chandler Gatenbee, et al.. "Cytokine expression and microglial activation in progressive supranuclear palsy." Parkinsonism & Related Disorders Vol. 17 Iss. 9 (2011) p. 683 - 688 ISSN: 1353-8020
Available at: http://works.bepress.com/fabian-crespo/4/