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NovaSil Clay Does Not Affect the Concentrations of Vitamins A and E and Nutrient Minerals in Serum Samples from Ghanaians at High Risk for Aflatoxicosis
Food Additives and Contaminants (2008)
  • Evans Afriyie-Gyawu, Georgia Southern University
  • Z. Wang
  • Nii-Ayi Ankrah, University of Ghana
  • Li Xu, Texas Tech University
  • Natalie M. Johnson
  • Lili Tang, Texas Tech University
  • Hongxia Guan
  • Henry J. Huebner
  • Pauline E. Jolly
  • William O. Ellis, Kwame Nkrumah University of Science and Technology
  • R. Taylor
  • B. Brattin
  • David Ofori-Adjei, University of Ghana
  • Jonathan H. Williams, University of Georgia
  • Jia-Sheng Wang
  • Timothy D. Phillips
Abstract

To assess the potential interference of NovaSil (NS) clay with micronutrients in humans, vitamins A and E and minerals (15 nutrient and 15 non-nutrient minerals) were measured in serum samples from a 3-month intervention trial with NS. Participants (n = 177) were randomly divided into three groups that received 3.0 g NS day−1 (high dose, HD), 1.5 g NS day−1 (low dose, LD), or placebo (PL). Levels of vitamins A and E in serum were comparable among the three study groups at baseline, 1 month and 3 months of NS intervention. Gender-stratified non-parametric mixed-effect model analysis showed no significant effects of dose and dose–time interaction for levels of vitamins A and E. A significant time effect was detected; however, it was limited to an increase in vitamin E in the male participants over the course of the study. No significant differences were found in levels of the nutrient and non-nutrient minerals between the HD and PL groups at baseline and 3 months of NS intervention, except for strontium levels. Strontium was significantly increased (p < 0.001) in the HD group (male = 113.65 ± 28.00 µg l−1; female = 116.40 ± 24.26 µg l−1) compared with the PL group (male = 83.55 ± 39.90 µg l−1; female = 90.47 ± 25.68 µg l−1) following the 3-month intervention with NS. These results, combined with safety and efficacy data, confirm that NS clay is highly effective in reducing aflatoxin exposure and acts as a selective enterosorbent that does not affect the serum concentrations of important vitamins and nutrient minerals in humans.

Keywords
  • NovaSil clay,
  • Aflatoxin,
  • Enterosorbent,
  • Micronutrients,
  • Vitamin A,
  • Vitamin E,
  • Minerals,
  • Heavy metals
Publication Date
2008
Citation Information
Evans Afriyie-Gyawu, Z. Wang, Nii-Ayi Ankrah, Li Xu, et al.. "NovaSil Clay Does Not Affect the Concentrations of Vitamins A and E and Nutrient Minerals in Serum Samples from Ghanaians at High Risk for Aflatoxicosis" Food Additives and Contaminants Vol. 25 Iss. 7 (2008)
Available at: http://works.bepress.com/evans_afriyie-gyawu/19/