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Aflatoxin-Albumin Adducts and Correlation with Decreased Serum Levels of Vitamins A & E in an Adult Ghanaian Population
Food Additives and Contaminants (2009)
  • Lili Tang, Texas Tech University
  • Li Xu, Texas Tech University
  • W. Liu
  • P. Wang
  • Y. Tang
  • Z. Wang
  • Henry Huebner, Texas A & M University - College Station
  • Nii-Ayi Ankrah, University of Ghana
  • David Ofori-Adjei, University of Ghana
  • Jonathan H. Willaims, University of Georgia
  • Jia-Sheng Wang, Texas Tech University
  • Timothy Phillips, Texas A & M University - College Station
  • Evans Afriyie-Gyawu, Georgia Southern University
Abstract

A study of aflatoxin (AF) exposure and the levels of vitamins A and E was carried out with a group of 507 Ghanaian participants. AFB1–albumin adducts (AFB-AA) were measured by radioimmunoassay and vitamins A and E were measured by high-performance liquid chromatography (HPLC). The average level of serum AFB-AA was 0.940.64 (range¼0.1–4.44) pmol mg1 albumin. Mean levels of vitamins A and E were 1.320.48 (range¼0.41–4.85)mmol l1 and 15.684.12 (range¼6.35–30.40)mmol l1, respectively. A significantly negative correlation was found between serum AFB-AA and vitamin A levels (r¼ 0.110, p¼0.013). An even stronger, significant negative, correlation was found between serum AFB-AA and vitamin E levels (r¼ 0.149, p50.001). Serum AFB-AA levels were statistically higher (median¼0.985 pmol mg1 albumin) in subjects who had low levels of both vitamins A and E as compared with the levels (median¼0.741 pmol mg1 albumin) subjects who had high vitamins A and E levels (ptrend¼0.001). To verify these findings, blood samples were again collected from 165 of the 507 people 3 months after the initial collection. Significantly negative correlations were confirmed between levels of serum AFB-AA and both vitamins A (r¼ 0.232, p¼0.003) and E (r¼ 0.178, p¼0.023). Again, high serum AFB-AA concentrations (median¼1.578 pmol mg1 albumin) were found in subjects with low levels of vitamins A and E compared with the concentrations (median¼1.381 pmol mg1 albumin) in subjects with high levels of vitamins A and E (ptrend¼0.002). These data show that AF exposure was associated with decreased levels of serum vitamins A and E in high-risk human populations, which may significantly influence the incidence of AF-related adverse health effects.

Keywords
  • Aflatoxins,
  • Aflatoxin-albumin adducts,
  • Vitamin A,
  • Vitamin E,
  • Ghanaian
Publication Date
2009
Citation Information
Lili Tang, Li Xu, W. Liu, P. Wang, et al.. "Aflatoxin-Albumin Adducts and Correlation with Decreased Serum Levels of Vitamins A & E in an Adult Ghanaian Population" Food Additives and Contaminants Vol. 26 Iss. 1 (2009)
Available at: http://works.bepress.com/evans_afriyie-gyawu/18/