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Article
The Logistic Growth Model as an Approximating Model for Viral Load Measurements of Influenza A Virus
Mathematics and Computers in Simulation
  • Abbiana Arenas, Nova Southeastern University
  • Neil B. Thackar, Nova Southeastern University
  • Evan Haskell, Nova Southeastern University
Document Type
Article
Publication Date
3-1-2017
Keywords
  • Influenza,
  • Logistic Growth,
  • Model Selection,
  • Identifiability Analysis,
  • Adaptive Immune-Response,
  • Infection,
  • Dynamics,
  • Mice,
  • Identifiability,
  • Kinetics,
  • Defense,
  • Cells
Abstract

Detailed kinetic models of viral replication have led to greater understanding of disease progression and the effects of therapy. Viral load is important as a driver of the immune response to the viral infection and in determining the infectiousness of an infected individual. However in many cases when examining the immune response or spread of infection, it may be sufficient to have a more parsimonious model of viral load than the detailed kinetic models. Here we review properties of detailed kinetic models of Influenza A virus and discuss the use of a logistic growth model to approximate viral load. We make application of the tools of identifiability analysis and model selection to assess the logistic growth model as a proxy for viral load. We find that the parameters of the logistic growth model can be related to the parameters of a detailed viral kinetic model, the logistic growth model makes a strong fit to viral load data with a small number of parameters, and that these parameters can be reliably identified from viral load data generated by a detailed kinetic model.

Comments

(C) 2016 International Association for Mathematics and Computers in Simulation (IMACS). Published by Elsevier B.V. All rights reserved.

DOI
10.1016/j.matcom.2016.10.002
Citation Information
Abbiana Arenas, Neil B. Thackar and Evan Haskell. "The Logistic Growth Model as an Approximating Model for Viral Load Measurements of Influenza A Virus" Mathematics and Computers in Simulation Vol. 133 Iss. SI (2017) p. 206 - 222 ISSN: 0378-4754
Available at: http://works.bepress.com/evan-haskell/73/