Contribution to Book
A repeated challenge humoral immune response model
Proceedings of the Sixth Symposium on B.E.E.R.
(2015)
Abstract
Influenza vaccination is the best method of control for seasonal influenza outbreak. Vaccination depends on the host’s humoral immunity to clear virus infections. However the dynamics of humoral immunity on controlling the virus titers have been relatively unexplored. Most specifically the qualitative impact of humoral immunity during primary and secondary immune response has not been explored. Here we establish a parsimonious model to study the significance of B cells and antibody that neutralizes virus and terminate infection. We demonstrate the effectiveness of the humoral immune response during a primary infection and see that memory formation is a slow process that may lead to detrimental conditions for the host in the absence of other immune effectors. However once formed memory B cells are highly efficacious in controlling subsequent challenges by the host.
Disciplines
Publication Date
2015
Publisher
McGraw-Hill
ISBN
978-1308452098
Citation Information
Abbiana R Arenas, Samita Andreansky and Evan C Haskell. "A repeated challenge humoral immune response model" Proceedings of the Sixth Symposium on B.E.E.R. (2015) p. 198 - 205 Available at: http://works.bepress.com/evan-haskell/100/