Federal grants-in-aid have been a major device for stimulating new programs for improving the quality of life in the United States. This paper assesses the impact of one such grant-in-aid (Maternal and Child Health Services) on improvements in infant health in the American states in the 1950–1964 period. The analysis indicates that how much a state's Maternal and Child Health Services grant was increased or decreased had no systematic overal impact on later changes in that state's infant, neonatal, and fetal mortality indicators. In addition, such grant changes had no major systematic impact when controlling for per capita income, changes in per capita income, population, innovation tendencies, and administrative professionalism.