Skip to main content
Article
Antenatal risk factors, cytokines and the development of atopic disease in early childhood
Department of Pediatrics Faculty Papers
  • Esther K. Chung, Thomas Jefferson Universty and A.I. duPont Hospital for Children
  • Rachel L. Miller, Columbia University
  • Michael T. Wilson, Harvard College
  • Stephen J. McGeady, Thomas Jefferson University and A.I. duPont Hospital for Children
  • Jennifer F. Culhane, Drexel University
Document Type
Article
Publication Date
1-1-2007
Comments
This article has been peer reviewed. It is the author's final version prior to publication in the Archives of Disease in Childhood: Fetal and Neonatal Edition, 92(1): F68-F73, January 2007. The published version is available at http://fn.bmj.com/cgi/content/abstract/92/1/F68; copyright is retained by BMJ Publishing Group.
Abstract

Atopic diseases are complex entities influenced by an array of risk factors including genetic predisposition, environmental allergens, antenatal exposures, infections and psychosocial factors. One proposed mechanism by which these risk factors contribute to the development of atopic disease is through alterations in the production of T helper type 1 (Th1) and type 2 (Th2) cytokines. The objectives of this review are to discuss antenatal exposures that are associated with pediatric atopic diseases, to discuss the influence of the intrauterine environment on neonatal immune responses, to provide an overview of the Th1 and Th2 pathways and how they relate to atopic disease, and to summarize our current understanding of the association between cytokine responses in cord blood and the development of atopic disease in early childhood.

Citation Information
Esther K. Chung, Rachel L. Miller, Michael T. Wilson, Stephen J. McGeady, et al.. "Antenatal risk factors, cytokines and the development of atopic disease in early childhood" (2007)
Available at: http://works.bepress.com/esther_chung/2/