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Bivariate analysis of basal serum anti-Müllerian hormone measurements and human blastocyst development after IVF.
Obstetrics and Gynaecology Articles
  • Eric Scott Sills, Royal College of Surgeons in Ireland
  • Gary S Collins, University of Oxford
  • Adam C Brady, University of Massachusetts School of Medicine
  • David J Walsh, Royal College of Surgeons in Ireland
  • Kevin D Marron, Royal College of Surgeons in Ireland
  • Alison C Peck, Pacific Reproductive Center, California, USA
  • Anthony PH Walsh, Royal College of Surgeons in Ireland
  • Rifaat D Salem, Pacific Reproductive Center, California, USA
Peer Reviewed
1
Document Type
Article
Publication Date
1-12-2011
Keywords
  • blastocyst,
  • IVF,
  • anti-Müllerian hormone,
  • AMH
Comments

This article is also available at http://www.rbej.com/content/9/1/153

Abstract
BACKGROUND: To report on relationships among baseline serum anti-Müllerian hormone (AMH) measurements, blastocyst development and other selected embryology parameters observed in non-donor oocyte IVF cycles. METHODS: Pre-treatment AMH was measured in patients undergoing IVF (n = 79) and retrospectively correlated to in vitro embryo development noted during culture. RESULTS: Mean (+/- SD) age for study patients in this study group was 36.3 ± 4.0 (range = 28-45) yrs, and mean (+/- SD) terminal serum estradiol during IVF was 5929 +/- 4056 pmol/l. A moderate positive correlation (0.49; 95% CI 0.31 to 0.65) was noted between basal serum AMH and number of MII oocytes retrieved. Similarly, a moderate positive correlation (0.44) was observed between serum AMH and number of early cleavage-stage embryos (95% CI 0.24 to 0.61), suggesting a relationship between serum AMH and embryo development in IVF. Of note, serum AMH levels at baseline were significantly different for patients who did and did not undergo blastocyst transfer (15.6 vs. 10.9 pmol/l; p = 0.029). CONCLUSIONS: While serum AMH has found increasing application as a predictor of ovarian reserve for patients prior to IVF, its roles to estimate in vitro embryo morphology and potential to advance to blastocyst stage have not been extensively investigated. These data suggest that baseline serum AMH determinations can help forecast blastocyst developmental during IVF. Serum AMH measured before treatment may assist patients, clinicians and embryologists as scheduling of embryo transfer is outlined. Additional studies are needed to confirm these correlations and to better define the role of baseline serum AMH level in the prediction of blastocyst formation.
PubMed ID
22136508
DOI Link
10.1186/1477-7827-9-153
Citation Information
Sills ES, Collins GS, Brady AC, Walsh DJ, Marron KD, Peck AC, Walsh AP, Salem RD. Bivariate analysis of basal serum anti-Müllerian hormone measurements and human blastocyst development after IVF. Reproductive Biology and Endocrinology. 2011;9:153.