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Endothelial function in patients with familial Mediterranean fever-related amyloidosis and association with cardiovascular events
Rheumatology (United Kingdom)
  • Mahmut I. Yilmaz
  • Erkan Demirkaya, Gulhane Military Medical Academy
  • Cengizhan Acikel, RandD Engineer
  • Mehmet Saldir, Gulhane Military Medical Academy
  • Servet Akar, Eylül University
  • Tuncer Cayci
  • Mutlu Saglam
  • Hilmi U. Unal
  • Mahmut Gok
  • Adem Polat, Gulhane Military Medical Academy
  • Hakki Cetinkaya
  • Tayfun Eyileten
  • Sebahattin Sari
  • Ali O. Yildirim
  • Alper Sonmez, Gulhane Military Medical Academy
  • Yusuf Oguz
  • Abdulgaffar Vural
  • Seza Ozen, Hacettepe Üniversitesi
  • Juan Jesús Carrero, Center for Molecular Medicine
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Objectives. Secondary amyloidosis is the most important complication of FMF and endothelial function is more severely impaired. Elevated asymmetric dimethyl arginine (ADMA) may mediate the excess cardiovascular disease (CVD) risk of this group. We aimed to compare endothelial function characteristics, including ADMA, in patients with FMF-related amyloidosis and primary glomerulopathies and to define risk factors for a CVD event. Methods. We undertook a cross-sectional study with prospective follow-up including consecutive patients with FMF-related amyloidosis (n = 98) or other non-diabetic glomerulopathies (n = 102). All patients had nephrotic-range proteinuria and normal glomerular filtration rate. Flow-mediated dilatation (FMD) was assessedand ADMA levels, CRP and pentraxin 3 (PTX3) were determined. Patients were followed for cardiovascular events. Results. Amyloidosis patients secondary to FMF showed higher levels of ADMA, CRP and PTX3 and lower FMD as compared with patients with other glomerulopathies. Cardiovascular events (n = 54) were registered during 3 years of follow-up. Increased ADMA levels and lower FMD were observed in patients with cardiovascular risk in both groups, but especially in individuals with amyloidosis.Conclusion. Patients with FMF-related amyloidosis have increased CVD event risk, probably related to the high ADMA levels, elevated inflammatory markers and decreased FMD measures observed in these patients.

Citation Information
Mahmut I. Yilmaz, Erkan Demirkaya, Cengizhan Acikel, Mehmet Saldir, et al.. "Endothelial function in patients with familial Mediterranean fever-related amyloidosis and association with cardiovascular events" Rheumatology (United Kingdom) Vol. 53 Iss. 11 (2014) p. 2002 - 2008
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