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Primate microRNAs miR-220 and miR-492 lie within processed pseudogenes
The Journal of heredity
  • Eric J. Devor, University of Iowa
Document Type
Peer Reviewed
Publication Date
NLM Title Abbreviation
J Hered
PubMed ID
DOI of Published Version

MicroRNAs (miRNAs) are a new and abundant class of small, noncoding RNAs. To date, the evolutionary history of most of these loci appears to be marked by duplication and divergence. The ultimate origin of miRNAs remains an open question. A survey of the genomic context of more than 300 human miRNA loci revealed that two primate-specific miRNAs, miR-220 and miR-492, each lie within a processed pseudogene. In silico and in vitro examinations of these two loci suggest that this is a rare phenomenon requiring the juxtaposition of a specific combination of factors. Thus it appears that, while processed pseudogenes are good candidates for miRNA incubators, it is unlikely that more than a very small percentage of new miRNAs arise this way.

  • Animals,
  • Base Sequence,
  • Humans,
  • Macaca mulatta/genetics,
  • MicroRNAs/genetics,
  • Nucleic Acid Conformation,
  • Pan troglodytes/genetics,
  • Pongo pygmaeus/genetics,
  • Primates/genetics,
  • Pseudogenes/genetics,
  • Sequence Alignment
Published Article/Book Citation
The Journal of heredity, 97:2 (2006) pp.186-190.
Citation Information
Eric J. Devor. "Primate microRNAs miR-220 and miR-492 lie within processed pseudogenes" The Journal of heredity Vol. 97 Iss. 2 (2006) p. 186 - 190 ISSN: 0022-1503
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