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Article
An X chromosome microRNA cluster in the marsupial species Monodelphis domestica
The Journal of heredity
  • Eric J. Devor, University of Iowa
  • L. Huang
  • A. Wise
  • A. S. Peek
  • P. B. Samollow
Document Type
Article
Peer Reviewed
1
Publication Date
9-1-2011
NLM Title Abbreviation
J Hered
PubMed ID
21685406
DOI of Published Version
10.1093/jhered/esr050
Abstract

MicroRNAs (miRNAs) are an important class of posttranscriptional gene expression regulators. In the course of mapping novel marsupial-specific miRNAs in the genome of the gray short-tailed opossum, Monodelphis domestica, we encountered a cluster of 39 actual and potential miRNAs spanning 102 kb of the X chromosome. Analysis of the cluster revealed that 37 of the 39 miRNAs are predicted to form thermodynamically stable hairpins, and at least 3 members have been directly cloned from M. domestica tissues. The sequence characteristics of these miRNAs suggest that they all descended from a single common ancestor. Further, 2 distinct families appear to have diversified from the ancestral sequence through different duplication mechanisms: one through a series of simple tandem duplications and the other through a recurrent transposon-mediated duplication process.

Keywords
  • Animals,
  • Base Sequence,
  • Chromosomes,
  • Chromosomes,
  • Mammalian/genetics,
  • Gene Expression Regulation,
  • Gene Order,
  • Male,
  • MicroRNAs/genetics,
  • Molecular Sequence Data,
  • Monodelphis/classification/genetics,
  • Multigene Family,
  • Phylogeny,
  • Reproduction/genetics,
  • Sequence Alignment,
  • X Chromosome/genetics
Published Article/Book Citation
The Journal of heredity, 102:5 (2011) pp.577-583.
Citation Information
Eric J. Devor, L. Huang, A. Wise, A. S. Peek, et al.. "An X chromosome microRNA cluster in the marsupial species Monodelphis domestica" The Journal of heredity Vol. 102 Iss. 5 (2011) p. 577 - 583 ISSN: 1465-7333
Available at: http://works.bepress.com/eric_devor/49/