An X chromosome microRNA cluster in the marsupial species Monodelphis domesticaThe Journal of heredity
NLM Title AbbreviationJ Hered
DOI of Published Version10.1093/jhered/esr050
AbstractMicroRNAs (miRNAs) are an important class of posttranscriptional gene expression regulators. In the course of mapping novel marsupial-specific miRNAs in the genome of the gray short-tailed opossum, Monodelphis domestica, we encountered a cluster of 39 actual and potential miRNAs spanning 102 kb of the X chromosome. Analysis of the cluster revealed that 37 of the 39 miRNAs are predicted to form thermodynamically stable hairpins, and at least 3 members have been directly cloned from M. domestica tissues. The sequence characteristics of these miRNAs suggest that they all descended from a single common ancestor. Further, 2 distinct families appear to have diversified from the ancestral sequence through different duplication mechanisms: one through a series of simple tandem duplications and the other through a recurrent transposon-mediated duplication process.
- Base Sequence,
- Gene Expression Regulation,
- Gene Order,
- Molecular Sequence Data,
- Multigene Family,
- Sequence Alignment,
- X Chromosome/genetics
Published Article/Book CitationThe Journal of heredity, 102:5 (2011) pp.577-583.
Citation InformationEric J. Devor, L. Huang, A. Wise, A. S. Peek, et al.. "An X chromosome microRNA cluster in the marsupial species Monodelphis domestica" The Journal of heredity Vol. 102 Iss. 5 (2011) p. 577 - 583 ISSN: 1465-7333
Available at: http://works.bepress.com/eric_devor/49/