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Article
Genetic structure of the Aleuts and Circumpolar populations based on mitochondrial DNA sequences: a synthesis
American Journal of Physical Anthropology
  • M. Zlojutro
  • R. Rubicz
  • Eric J. Devor, University of Iowa
  • V. A. Spitsyn
  • S. V. Makarov
  • K. Wilson
  • M. H. Crawford
Document Type
Article
Peer Reviewed
1
Publication Date
3-1-2006
NLM Title Abbreviation
Am J Phys Anthropol
PubMed ID
16323192
DOI of Published Version
10.1002/ajpa.20287
Abstract

The mtDNA variation of 198 Aleuts, as well as North American and Asian populations drawn from the literature, were analyzed to reconstruct the Aleuts' genetic prehistory and to investigate their role in the peopling of the Circumarctic region. From median-joining network analysis, three star-like clusters were identified in the Aleuts within the following subhaplogroups: A3, A7 (an Aleut-specific subclade of A3), and D2. Mismatch analyses, neutrality test scores, and coalescent time estimates for these three components provided evidence of two expansion events, one occurring at approximately 19,900 B.P. and the other at 5,400 B.P. Based on these findings and evidence from the archaeological data, four general models for the genetic prehistory of the Aleutian Island chain are proposed: 1) biological continuity involving a kin-structured peopling of the archipelago; 2) intrusion and expansion of a non-native biface-producing population dominated by subhaplogroup D2; 3) amalgamation of Arctic Small Tool tradition peoples characterized by D2 with an older Anangula substratum; and 4) biological continuity with significant gene flow from neighboring populations of the Alaskan mainland and Kodiak Island. The Aleut mtDNAs are consistent with the Circumarctic pattern by the fixation of A3 and D2, and the exhibition of depressed diversity levels relative to Amerind and Siberian groups. The results of this study indicate a broad postglacial reexpansion of Na-Dene and Esko-Aleuts from reduced populations within northern North America, with D2 representing a later infusion of Siberian mtDNAs into the Beringian gene pool.

Keywords
  • Arctic Regions,
  • Cluster Analysis,
  • DNA,
  • Mitochondrial/genetics,
  • Evolution,
  • Molecular,
  • Genetic Variation,
  • Genetics,
  • Population,
  • Geography,
  • Haplotypes/genetics,
  • Humans,
  • Inuits/genetics,
  • Models,
  • Genetic,
  • Population Dynamics
Published Article/Book Citation
American Journal of Physical Anthropology, 129:3 (2006) pp.446-464.
Citation Information
M. Zlojutro, R. Rubicz, Eric J. Devor, V. A. Spitsyn, et al.. "Genetic structure of the Aleuts and Circumpolar populations based on mitochondrial DNA sequences: a synthesis" American Journal of Physical Anthropology Vol. 129 Iss. 3 (2006) p. 446 - 464 ISSN: 0002-9483
Available at: http://works.bepress.com/eric_devor/16/