Combining Metabolic Engineering and Electrocatalysis: Application to the Production of Polyamides from SugarAngewandte Chemie International Edition
Publication VersionSubmitted Manuscript
AbstractBiorefineries aim to convert biomass to a spectrum of products ranging from biofuels to specialty chemicals. To achieve economically sustainable conversion it is crucial to streamline the catalytic and downstream processing steps. Here we report a route that integrates bio- and chemical catalysis to convert glucose into bio-based unsaturated nylon 6,6. An engineered strain of Saccharomyces cerevisiae, with the highest reported muconic acid titer of 559.5 mg L-1 in yeast, was used as the initial biocatalyst to convert glucose into muconic acid. Without any separation, muconic acid was further electrocatalytically hydrogenated to 3-hexenedioic acid with 94% yield, despite the presence of all the biogenic impurities. Bio-based unsaturated nylon 6,6 (unsaturated polyamide 6,6) was finally obtained by polymerization of 3-hexenedioic acid with hexamethylenediamine, demonstrating the integrated design of bio-based polyamides from glucose.
Copyright OwnerWiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Citation InformationMiguel Suastegui, John E. Matthiesen, Jack M. Carraher, Nacú Hernández, et al.. "Combining Metabolic Engineering and Electrocatalysis: Application to the Production of Polyamides from Sugar" Angewandte Chemie International Edition Vol. 55 Iss. 7 (2016) p. 2368 - 2373
Available at: http://works.bepress.com/eric_cochran/21/