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Combining Metabolic Engineering and Electrocatalysis: Application to the Production of Polyamides from Sugar
Angewandte Chemie International Edition
  • Miguel Suastegui, Iowa State University
  • John E. Matthiesen, Iowa State University
  • Jack M. Carraher, Iowa State University
  • Nacú Hernández, Iowa State University
  • Natalia Rodriguez Quiroz, NSF Engineering Research Center for Biorenewable Chemicals
  • Adam Okerlund, NSF Engineering Research Center for Biorenewable Chemicals
  • Eric W. Cochran, Iowa State University
  • Zengyi Shao, Iowa State University
  • Jean-Philippe Tessonnier, Iowa State University
Document Type
Article
Publication Version
Submitted Manuscript
Publication Date
2-12-2016
DOI
10.1002/anie.201509653
Abstract
Biorefineries aim to convert biomass to a spectrum of products ranging from biofuels to specialty chemicals. To achieve economically sustainable conversion it is crucial to streamline the catalytic and downstream processing steps. Here we report a route that integrates bio- and chemical catalysis to convert glucose into bio-based unsaturated nylon 6,6. An engineered strain of Saccharomyces cerevisiae, with the highest reported muconic acid titer of 559.5 mg L-1 in yeast, was used as the initial biocatalyst to convert glucose into muconic acid. Without any separation, muconic acid was further electrocatalytically hydrogenated to 3-hexenedioic acid with 94% yield, despite the presence of all the biogenic impurities. Bio-based unsaturated nylon 6,6 (unsaturated polyamide 6,6) was finally obtained by polymerization of 3-hexenedioic acid with hexamethylenediamine, demonstrating the integrated design of bio-based polyamides from glucose.
Comments

This is the pre-peer reviewed version of the following article:Suastegui, Miguel, John E. Matthiesen, Jack M. Carraher, Nacu Hernandez, Natalia Rodriguez Quiroz, Adam Okerlund, Eric W. Cochran, Zengyi Shao, and Jean‐Philippe Tessonnier. "Combining metabolic engineering and electrocatalysis: Application to the production of polyamides from sugar." Angewandte Chemie International Edition 55, no. 7 (2016): 2368-2373., which has been published in final form at DOI: 10.1002/anie.201509653. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Copyright Owner
Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Language
en
File Format
application/pdf
Citation Information
Miguel Suastegui, John E. Matthiesen, Jack M. Carraher, Nacú Hernández, et al.. "Combining Metabolic Engineering and Electrocatalysis: Application to the Production of Polyamides from Sugar" Angewandte Chemie International Edition Vol. 55 Iss. 7 (2016) p. 2368 - 2373
Available at: http://works.bepress.com/eric_cochran/21/