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Article
Efficacy of Female Rat Models in Translational Cardiovascular Aging Research
Pharmaceutical Science and Research
  • Kevin M. Rice, Marshall University
  • J. C. Fannin
  • C. Gillette
  • Eric Blough, Marshall University
Document Type
Article
Publication Date
12-31-2014
Abstract
Cardiovascular disease is the leading cause of death in women in the United States. Aging is a primary risk factor for the development of cardiovascular disease as well as cardiovascular-related morbidity and mortality. Aging is a universal process that all humans undergo; however, research in aging is limited by cost and time constraints. Therefore, most research in aging has been done in primates and rodents; however it is unknown how well the effects of aging in rat models translate into humans. To compound the complication of aging gender has also been indicated as a risk factor for various cardiovascular diseases. This review addresses the systemic pathophysiology of the cardiovascular system associated with aging and gender for aging research with regard to the applicability of rat derived data for translational application to human aging.
Comments

The copy of record is available from the publisher at http://dx.doi.org/10.1155/2014/153127. Copyright © 2014 K. M. Rice et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citation Information
K. M. Rice, J. C. Fannin, C. Gillette, and E. R. Blough, “Efficacy of Female Rat Models in Translational Cardiovascular Aging Research,” Journal of Aging Research, vol. 2014, Article ID 153127, 14 pages, 2014. doi:10.1155/2014/153127