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Article
Cerium oxide nanoparticles inhibit lipopolysaccharide inducedMAP kinase/NF-kB mediated severe sepsis
Pharmaceutical Science and Research
  • Mani Maheshwari, Marshall University
  • Nandini Manne, PhD, Marshall University
  • Shinichi Asano
  • Eric Blough, Marshall University
  • Kevin M Rice, Marshall University
  • Niraj Nepa,, Marshall University
  • Erin Fankhanel, Marshall University
Document Type
Article
Publication Date
5-8-2015
Abstract
The life threatening disease of sepsis is associated with high mortality. Septic patient survivability with currently available treatments has failed to improve. The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can be prevented by cerium oxide nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the methods processing of raw data related to our study published in Biomaterials (Selvaraj et al., Biomaterials, 2015, In press) and Data in Brief (Selvaraj et al., Data in Brief, 2015, In Press). The data present here provides confirmation of cerium oxide nanoparticle treatments ability to prevent the LPS induced sepsis associated changes in physiological, blood cell count, inflammatory protein and growth factors in vivo. In vitro assays investigation the treated of macrophages cells with different concentrations of cerium oxide nanoparticle demonstrate that concentration of cerium oxide nanoparticles below 1 µg/ml did not significantly influence cell survival as determined by the MTT assay.
Comments

The copy of record is available from the publisher at http://dx.doi.org/10.1016/j.dib.2015.04.023. Copyright © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Citation Information
Selvaraj V, Nepal N, Rogers S, Manne ND, Arvapalli R, Rice KM, Asano S, Fankenhanel E, Ma JY, Shokuhfar T, Maheshwari M, Blough ER. Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis. Data in Brief. 2015;8(4):105-115.