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Article
A new DNA nanostructure, the G-wire, imaged by scanning probe microscopy
Nucleic Acids Research
  • Thomas C. Marsh, Iowa State University
  • James Vesenka, Iowa State University
  • Eric Henderson, Iowa State University
Document Type
Article
Publication Version
Published Version
Publication Date
1-1-1995
DOI
10.1093/nar/23.4.696
Abstract

G-DNA is a polymorphic family of quadruple helical nucleic acid structures containing guanine tetrad motifs [G-quartets; Willlamson, J. R., Raghuraman.M.K. and CechJ.R. (1989) Cell 59, 871–880; Williamson. J. R. (1993) Proc. Natl. Acad. Scl . USA 90, 3124–3124]. Guanine rich oligonucleotides that are self-complimentary, as found in many telomeric G-strand repeat sequences, form G-DNA in the presence of mono-valent and/or divalent metal cations. In this report we use the atomic force microscope (AFM) to explore the structural characteristics of long, linear polymers formed by the telomeric oligonucleotide d(GGGG TTGGGG) in the presence of specific metal cations. In the AFM these polymers, termed G-wires, appear as filaments whose height and length are determined by the metal ions present during the self-assembly process. The highly ordered, controllable serf-assembly of G-wires could provide a basis for developing advanced blomaterials.

Comments

This article is from Nucleic Acids Research 23 (1995): 696, doi: 10.1093/nar/23.4.696. Posted with permission.

Copyright Owner
Oxford University Press
Language
en
File Format
application/pdf
Citation Information
Thomas C. Marsh, James Vesenka and Eric Henderson. "A new DNA nanostructure, the G-wire, imaged by scanning probe microscopy" Nucleic Acids Research Vol. 23 Iss. 4 (1995) p. 696 - 700
Available at: http://works.bepress.com/eric-henderson/41/