Skip to main content
Unpublished Paper
Programmable DNA Nanosystem for Molecular Interrogation
Scientific Reports
  • Davita Mathur, United States Naval Research Laboratory
  • Eric R. Henderson, Iowa State University
Document Type
Article
Publication Version
Published Version
Publication Date
6-7-2016
DOI
10.1038/srep27413
Abstract

We describe a self-assembling DNA-based nanosystem for interrogating molecular interactions. The nanosystem contains a rigid supporting dumbbell-shaped frame, a cylindrical central core, and a mobile ring that is coaxial with the core. Motion of the ring is influenced by several control elements whose force-generating capability is based on the transition of single-stranded DNA to double-stranded DNA. These forces can be directed to act in opposition to adhesive forces between the ring and the frame thereby providing a mechanism for molecular detection and interrogation at the ring-frame interface. As proof of principle we use this system to evaluate base stacking adhesion and demonstrate detection of a soluble nucleic acid viral genome mimic.

Comments

This article is from Scientific Reports 6 (2016): 27413, doi: 10.1038/srep27413.

Rights
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.
Language
en
File Format
application/pdf
Citation Information
Davita Mathur and Eric R. Henderson. "Programmable DNA Nanosystem for Molecular Interrogation" Scientific Reports Vol. 6 (2016) p. 27413
Available at: http://works.bepress.com/eric-henderson/13/