"Identification of the telomeric sequence of the acellular slime molds Didymium iridis and Physarum potycephalum" by James Forney

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Identification of the telomeric sequence of the acellular slime molds Didymium iridis and Physarum potycephalum

Nucleic Acids Research (1987)

James Forney, University of California, Berkeley
Eric R. Henderson, University of California, Berkeley
Elizabeth H. Blackburn, University of California, Berkeley

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Abstract

We have determined the telomeric DNA sequence of the acellular slime molds DidymiumIridis and Physarumpolycephalum. In both organisims the telomeres consist of tandem repeats of the hexamer 5′(TTAGGG)3′. This sequence was determined by cloning and sequencing the telomeric fragment of the linear extrachromosomal ribosomal DNA from Didymium as well as direct end labeling and sequencing the rDNA from both organisms. Interestingly, this sequence is identical to the telomeric DNA sequence of the flagellated protozoan Trypanosomabrucel. and suggests that despite the diversity of telomeric sequences previously determined in lower eukaryotes, the necessity to create functional telomeres has led to constraints on these sequences.

Disciplines

Publication Date

November 25, 1987

DOI

10.1093/nar/15.22.9143

Publisher Statement

1987 Copyright IRL Press Limited, Oxford, England

Citation Information

James Forney, Eric R. Henderson and Elizabeth H. Blackburn. "Identification of the telomeric sequence of the acellular slime molds Didymium iridis and Physarum potycephalum" Nucleic Acids Research Vol. 15 Iss. 22 (1987) p. 9143 - 9152
Available at: http://works.bepress.com/eric-henderson/11/