Article
Essential role of endogenously synthesized tylosin for induction of ermSF in Streptomyces fradiae
Antimicrobial Agents and Chemotherapy
Document Type
Article
Abstract
We compared ermSF induction in wild-type Streptomyces fradiae NRRL B- 2702 and that in GS-14, a tylA mutant which cannot synthesize tylosin. Our findings suggest that (i) endogenously synthesized tylosin plays an obligatory role in ermSF induction and (ii) tylosin, or a biosynthetic intermediate beyond tylactone, has an 'autocrine' function that induces ErmSF synthesis, thereby enabling S. fradiae to resist higher levels of tylosin.
DOI
10.1128/aac.41.5.1203
Publication Date
1-1-1997
Citation Information
Erdogan Memili and Bernard Weisblum. "Essential role of endogenously synthesized tylosin for induction of ermSF in Streptomyces fradiae" Antimicrobial Agents and Chemotherapy Vol. 41 Iss. 5 (1997) p. 1203 - 1205 ISSN: 00664804 Available at: http://works.bepress.com/erdogan-memili/32/