We read with great interest and would like to congratulate Yung et al18 for their very interesting study titled “Blood Pressure and Heart Rate Response to Posteriorly Directed Pressure Applied to the Cervical Spine in Young, Pain-Free Individuals: A Randomized, Repeated-Measures, Double-Blind, Placebo-Controlled Study,” published in the August 2014 issue of JOSPT. This study contributes to the knowledge of the effects of joint mobilization techniques, especially those applied on the spine, on autonomic nervous system modulation. The trial demonstrated a statistically significant drop in heart rate (HR) after an anterior-to-posterior (AP) cervical mobilization that did not occur in the placebo group. In addition, there was a statistically significant reduction in systolic blood pressure (BP) for both the intervention and placebo groups. However, due to the divergent results between this article and a recently published systematic review,4 we would like to add to the discussion.