Data on occupational safety and health are scant in the southern Africa region. Hence the negative impact of poor working conditions is unappreciated and the scientific basis for interventions and policy formulation is lacking. The objective of the study was to determine the prevalence and associated factors for occupational health hazards exposure in Zambia. We used data collected in the 2009 National Labour Force Survey. Unadjusted odds ratios (OR) and adjusted odds ratios (AOR) and their 95% confidence intervals (CI) were used to measure magnitudes of associations. Results from this study indicate Zambian workers are exposed to a broad range of occupational health hazards. The results of the present study could be useful for the formulation of a multi-sectoral approach aiming at the prevention and control of occupational hazards.