Article
Indinavir Increases Midazolam N-Glucuronidation in Humans: Identification of an Alternate CYP3A Inhibitor Using an In Vitro to In Vivo Approach
Drug metabolism and disposition: the biological fate of chemicals
Document Type
Article
Publication Date
7-1-2019
Disciplines
Abstract
Midazolam is a widely used index substrate for assessing effects of xenobiotics on CYP3A activity. A previous study involving human hepatocytes showed the primary route of midazolam metabolism, 1'-hydroxylation, shifted to
Specialty
Pharmacy
Citation Information
Dan-Dan Tian, Cathrine Leonowens, Emily J Cox, Vanessa González-Pérez, et al.. "Indinavir Increases Midazolam N-Glucuronidation in Humans: Identification of an Alternate CYP3A Inhibitor Using an In Vitro to In Vivo Approach" Drug metabolism and disposition: the biological fate of chemicals (2019) Available at: http://works.bepress.com/emilyj-cox/11/