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DNA Topology Influences Molecular Machine Lifetime in Human Serum
  • Sara Goltry, Boise State University
  • Natalya Hallstrom, Boise State University
  • Tyler Clark, Boise State University
  • Wan Kuang, Boise State University
  • Jeunghoon Lee, Boise State University
  • Cheryl Jorcyk, Boise State University
  • William B. Knowlton, Boise State University
  • Bernard Yurke, Boise State University
  • William L. Hughes, Boise State University
  • Elton Graugnard, Boise State University
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DNA nanotechnology holds the potential for enabling new tools for biomedical engineering, including diagnosis, prognosis, and therapeutics. However, applications for DNA devices are thought to be limited by rapid enzymatic degradation in serum and blood. Here, we demonstrate that a key aspect of DNA nanotechnology—programmable molecular shape—plays a substantial role in device lifetimes. These results establish the ability to operate synthetic DNA devices in the presence of endogenous enzymes and challenge the textbook view of near instantaneous degradation.

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Copyright Statement

This document was originally published by Royal Society of Chemistry Publishing in Nanoscale. This work is provided under Creative Commons Attribution License 3.0. Details regarding the use of this work can be found at: doi: 10.1039/C5NR02283E

Citation Information
Sara Goltry, Natalya Hallstrom, Tyler Clark, Wan Kuang, et al.. "DNA Topology Influences Molecular Machine Lifetime in Human Serum" Nanoscale (2015)
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