DNA methylation patterns and chromatin structure is significantly altered in many human neoplasms including bladder cancer. Aberrant promoter hypermethylation of tumor suppressor genes is now a well established mechanism of gene inactivation. Methyl binding proteins are believed to act as interpreters of DNA methylation signal. The methyl binding protein MeCP2 has been shown to bind specifically to the 5mCpGs that are flanked by A/T residues. (Klose R et al., 2005) and mediates transcriptional repression by recruiting histone deacetylases (Adrian Bird at al.,1998) and thus, serving as a bridge between two major regulatory mechanisms of gene expression-DNA methylation and histone deacetylation.