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Article
Returning Integrated Genomic Risk and Clinical Recommendations: The eMERGE Study
Genetics in Medicine
  • Ellen W. Clayton, Vanderbilt University Law School
  • Jodell E. Linder, Vanderbilt Institute for Clinical and Translational Research
  • Aimee Allworth, Vanderbilt Institute for Clinical and Trans. Res.
  • Sara T. Bland, Vand. Inst. for Clincial and Trans.
  • 100 others..., Van. Inst. for Clin. and Trans. Res.
Document Type
Article
Publication Date
1-6-2023
Keywords
  • Common variants,
  • Family history,
  • Genotyping,
  • Monogenic risks,
  • Polygenic risk scores
Abstract

The potential of artificial intelligence (AI) to reduce health care disparities and inequities is recognized, but it can also exacerbate these issues if not implemented in an equitable manner. This perspective identifies potential biases in each stage of the AI life cycle, including data collection, annotation, machine learning model development, evaluation, deployment, operationalization, monitoring, and feedback integration. To mitigate these biases, we suggest involving a diverse group of stakeholders, using human-centered AI principles. Human-centered AI can help ensure that AI systems are designed and used in a way that benefits patients and society, which can reduce health disparities and inequities. By recognizing and addressing biases at each stage of the AI life cycle, AI can achieve its potential in health care

Citation Information
Ellen W. Clayton, Jodell E. Linder, Aimee Allworth, Sara T. Bland, et al.. "Returning Integrated Genomic Risk and Clinical Recommendations: The eMERGE Study" Genetics in Medicine Vol. 25 Iss. 4 (2023) p. 100006 ISSN: 1098-3600
Available at: http://works.bepress.com/ellen-clayton/41/