Mobile devices (e.g., smartphones, personal digital assistants, and tablets) are evolving rapidly and growing exponentially in multiple facets around the globe. Specifically, mobile devices can be used as audio and video chat, reference guide, training tool, handoff facilitation, and decision support. Undoubtedly, there are clear advantages of leveraging this technology including automatic updates, portable and unobtrusive access to data, and time savings for documentation allowing clinicians more time for patient care. However, innovative technology brings new yet critical obstacles to overcome (e.g., usability and security). Thus, the current panel is designed to gather leading human factors and medical experts in the fields of clinical care, system design, and human-system interaction to provide their insight and perspective on the following question: What contributions can human factors science and medical experts combine to bring to bear on the development, implementation, and evaluation of mobile-based technology?