Skip to main content
Article
Defining Treatment Response and Remission in Child Anxiety: Signal Detection Analysis Using the Pediatric Anxiety Rating Scale
Journal of the American Academy of Child and Adolescent Psychiatry
  • Nicole E. Caporino
  • Douglas M. Brodman
  • Philip C. Kendall
  • Anne Marie Albano
  • Joel Sherrill
  • John Piacentini
  • Dara Sakolsky
  • Boris Birmaher
  • Scott N. Compton
  • Golda Ginsburg
  • Moira Rynn
  • James McCracken
  • Elizabeth A. Gosch, Philadelphia College of Osteopathic Medicine
  • Courtney Pierce Keeton
  • John March
  • John T. Walkup
Document Type
Article
Publication Date
1-1-2013
Abstract
OBJECTIVE: To determine optimal Pediatric Anxiety Rating Scale (PARS) percent reduction and raw score cut-offs for predicting treatment response and remission among children and adolescents with anxiety disorders. METHOD: Data were from a subset of youth (N = 438; 7-17 years of age) who participated in the Child/Adolescent Anxiety Multimodal Study (CAMS), a multi-site, randomized controlled trial that examined the relative efficacy of cognitive-behavioral therapy (CBT; Coping Cat), medication (sertraline [SRT]), their combination, and pill placebo for the treatment of separation anxiety disorder, generalized anxiety disorder, and social phobia. The clinician-rated PARS was administered pre- and posttreatment (delivered over 12 weeks). Quality receiver operating characteristic methods assessed the performance of various PARS percent reductions and absolute cut-off scores in predicting treatment response and remission, as determined by posttreatment ratings on the Clinical Global Impression scales and the Anxiety Disorders Interview Schedule for DSM-IV. Corresponding change in impairment was evaluated using the Child Anxiety Impact Scale. RESULTS: Reductions of 35% and 50% on the six-item PARS optimally predicted treatment response and remission, respectively. Post-treatment PARS raw scores of 8 to 10 optimally predicted remission. Anxiety improved as a function of PARS-defined treatment response and remission. CONCLUSIONS: Results serve as guidelines for operationalizing treatment response and remission in future research and in making cross-study comparisons. These guidelines can facilitate translation of research findings into clinical practice.
PubMed ID
23265634
Comments

This article was published in Journal of the American Academy of Child & Adolescent Psychiatry, Volume 52, Issue 1, January 2013, Pages 57-67.

The published version is available at http://dx.doi.org/10.1016/j.jaac.2012.10.006

Copyright © 2013 Elsevier Inc.

Citation Information
Nicole E. Caporino, Douglas M. Brodman, Philip C. Kendall, Anne Marie Albano, et al.. "Defining Treatment Response and Remission in Child Anxiety: Signal Detection Analysis Using the Pediatric Anxiety Rating Scale" Journal of the American Academy of Child and Adolescent Psychiatry Vol. 52 Iss. 1 (2013) p. 57 - 67
Available at: http://works.bepress.com/elizabeth_gosch/10/