Pharmacokinetics of penicillin G procaine versus penicillin G potassium and procaine hydrochloride in horses TitleAmerican Journal of Veterinary Research (2000)
To compare the pharmacokinetics of penicillin G and procaine in racehorses following i.m. administration of penicillin G procaine (PGP) with pharmacokinetics following i.m. administration of penicillin G potassium and procaine hydrochloride (PH).
6 healthy adult mares.
Horses were treated with PGP (22,000 units of penicillin G/kg of body weight, i.m.) and with penicillin G potassium (22,000 U/kg, i.m.) and PH (1.55 mg/kg, i.m.). A minimum of 3 weeks was allowed to elapse between drug treatments. Plasma and urine penicillin G and procaine concentrations were measured by use of high-pressure liquid chromatography.
Median elimination phase half-lives of penicillin G were 24.7 and 12.9 hours, respectively, after administration of PGP and penicillin G potassium. Plasma penicillin G concentration 24 hours after administration of penicillin G potassium and PH was not significantly different from concentration 24 hours after administration of PGP. Median elimination phase half-life of procaine following administration of PGP (15.6 hours) was significantly longer than value obtained after administration of penicillin G potassium and PH (1 hour).
CONCLUSIONS AND CLINICAL RELEVANCE:
Results suggest that i.m. administration of penicillin G potassium will result in plasma penicillin G concentrations for 24 hours after drug administration comparable to those obtained with administration of PGP Clearance of procaine from plasma following administration of penicillin G potassium and PH was rapid, compared with clearance following administration of PGP.
- Penicillins/administration & dosage,
Citation InformationC. Uboh, L. Soma, Y. Luo, Elizabeth McNamara (Brown), et al.. "Pharmacokinetics of penicillin G procaine versus penicillin G potassium and procaine hydrochloride in horses Title" American Journal of Veterinary Research Vol. 61 (2000) p. 811 - 815
Available at: http://works.bepress.com/elizabeth-brown/6/