Dried distiller’s grains with solubles (DDGS) are commonly fed at an inclusion of 10% or less in broiler diets with the added benefit of an improved ability to utilize the available nutrients compared to layers fed the same inclusion. Combined with intentional changes to processing to enhance the nutritional quality of DDGS, there is the potential to increase the utilization of DDGS when fed to broilers. The objective of this study was to determine the effects of feeding up to a 20% inclusion of high protein DDGS (HiP DDGS) on broiler performance in straight-run Cobb 500 broiler chickens. Birds fed diets containing 15 and 20% HiP DDGS gained less weight than control (p < 0.05) but did not have a different feed intake (FI). Birds fed the 20% HiP DDGS diet had a less efficient FCR than the control. Additional research is needed to further illustrate the value of feeding HiP DDGS in broiler chickens.