Article
Sevelamer Hydrochloride Binds Phosphate Released from Phytate in Chicks Fed 1α-Hydroxy Cholecalciferol
Journal of Renal Nutrition
(2013)
Abstract
Objective: Hyperphosphatemia in animal models of human renal disease has been linked to
increased risk of death. Phosphate binders (e.g. sevelamer hydrochloride) and plant-based, low
phosphate diets are used to reduce dietary phosphate load; however, animal models show that
treatment with active forms of vitamin D3 (e.g. calcitriol, a renal disease therapy) render plant
phytate phosphate available for absorption. Using an established chick model, the effectiveness
of sevelamer in preventing the apparent absorption of liberated phytate phosphate during active
vitamin D use was investigated in two separate experiments. Design: One-day old chicks were
fed ad libitum a basal diet containing deficient levels of inorganic phosphate (0.13%), but
adequate in total phosphate (0.40%, 0.23% as phytate phosphate), with or without the inclusion
of sevelamer hydrochloride (a phosphate binder), available inorganic phosphate, or active
vitamin D as 1-(OH) D3. Main outcome measures: Plasma phosphate (mg/dL), total bone ash
%, and weight gain (g). Results: Adding inorganic phosphate (0.36%) or 1-(OH) D3 increased
plasma phosphate 49% and 48% respectively, p<0.0001, and bone ash 23% and 19%,
respectively, p<0.001. The addition of 1% sevelamer to the basal diet with added inorganic
phosphate or 1-(OH) D3 significantly decreased plasma phosphate 28% and 20%, respectively,
p<0.01. Conclusion: Active vitamin D increased the availability of phytate phosphate for
intestinal absorption in an animal model; however, sevelamer effectively reduced the availability
of phosphate liberated from phytate. These data imply that sevelamer has phytate-phosphatebinding
efficacy.
Disciplines
Publication Date
January, 2013
DOI
10.1053/j.jrn.2011.12.005
Publisher Statement
Copyright © 2013 National Kidney Foundation, Inc.
Citation Information
Elizabeth A. Bobeck, Katie M. Meyer, Christian Helvig, Martin Petkovich, et al.. "Sevelamer Hydrochloride Binds Phosphate Released from Phytate in Chicks Fed 1α-Hydroxy Cholecalciferol" Journal of Renal Nutrition Vol. 23 Iss. 1 (2013) p. 21 - 27 Available at: http://works.bepress.com/elizabeth-bobeck/14/
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