SelectedWorks - Elisha R. Injeti, Ph.D.

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Scholarly Works of Elisha R. Injeti, Ph.D.

Professor of Pharmaceutical Sciences

After serving three years as a faculty member at a pharmacy school in India, Dr. Injeti pursued advanced studies at Loma Linda University in California, earning a Ph.D. in pharmacology. Upon completing his doctorate, he joined the faculty at the University of Toledo. In 2009, Dr. Injeti joined the Cedarville University School of Pharmacy as the Director for Research and Development. Dr. Injeti also serves as a fellow for Cedarville University’s Center for Bioethics. Dr. Injeti’s research interests include vascular biology, pharmacokinetics, drug interactions, and research ethics.

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About Elisha R. Injeti, Ph.D.

After serving three years as a faculty member at a pharmacy school in India, Dr. Injeti pursued advanced studies at Loma Linda University in California, earning a Ph.D. in pharmacology. Upon completing his doctorate, he joined the faculty at the University of Toledo. In 2009, Dr. Injeti joined the Cedarville University School of Pharmacy as the Director for Research and Development. Dr. Injeti also serves as a fellow for Cedarville University’s Center for Bioethics. Dr. Injeti’s research interests include vascular biology, pharmacokinetics, drug interactions, and research ethics.

Maturational Changes in Myosin Light Chain Kinase Activity in Ovine Carotids (Elisha R. Injeti) Faculty Dissertations (2008)

Vascular reactivity changes dramatically during postnatal maturation due in large part to developmental changes in myofilament calcium sensitivity. Recent findings suggest that reactivity of the thick filament component of calcium sensitivity is upregulated in fetal ...

Refereed Journal Articles (11)

A Research Update: Significance of Cytokine Storm and Diaphragm in COVID-19 (Ashwani Mittal, Anita Dua, Sanjeev Gupta, et al.) Current Research in Pharmacology and Drug Discovery (2021)

Emerging research on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) shows that it is spreading to multiple organs in addition to the respiratory system. Though the SARS-CoV2 enters the human body by binding to ACE2 receptors ...

Efficacy and Risk Profile of Anti-diabetic Therapies: Conventional vs Traditional Drugs - A Mechanistic Revisit to Understand Their Mode of Action (Prachi Gupta, Manju Bala, Sanjeev Gupta, et al.) Pharmacological Research (2016)

An increasing array of anti-diabetic drugs are available today, yet Type-2 diabetes mellitus (T2DM) - remains a life threatening disease, causing high mortality and morbidity in developing and developed countries. As of now, no effective ...

Skeletal Muscle Atrophy: Potential Therapeutic Agents and Their Mechanisms of Action (Vikas Dutt, Sanjeev Gupta, Rajesh Dabur, et al.) Pharmacological Research (2015)

Over the last two decades, new insights into the etiology of skeletal muscle wasting/atrophy under diverse clinical settings including denervation, AIDS, cancer, diabetes, and chronic heart failure have been reported in the literature. However, the ...

Characterization and Evaluation of 5-Fluorouracil-Loaded Solid Lipid Nanoparticles Prepared via a Temperature-Modulated Solidification Technique (Meghavi N. Patel, Sushant Lakkadwala, Mohamed S. Majrad, et al.) AAPS PharmSciTech (2014)

The aim of this research was to advance solid lipid nanoparticle (SLN) preparation methodology by preparing glyceryl monostearate (GMS) nanoparticles using a temperature-modulated solidification process. The technique was reproducible and prepared nanoparticles without the need ...

Presenting and Evaluating Qualitative Research: A Rejoinder to Anderson (2010) (Michael W. Firmin and Elisha R. Injeti) Indian Journal of Pharmaceutical Education and Research (2013)

This article is a response to Claire Anderson's (2010) special article on presenting and evaluating qualitative research that called for further exploration on how qualitative methodology can and should be integrated into pharmacy research agendas. ...

A Comparative Study of the Sulfation of Bile Acids and a Bile Alcohol by the Zebra danio (Danio rerio) and Human Cytosolic Sulfotransferases (SULTs) (Katsuhisa Kurogi, Matthew D. Krasowski, Elisha R. Injeti, et al.) Journal of Steroid Biochemistry and Molecular Biology (2011)

The current study was designed to examine the sulfation of bile acids and bile alcohols by the Zebra danio (Danio rerio) SULTs in comparison with human SULTs. A systematic analysis using the fifteen Zebra danio ...

Maximal Stimulation-induced in Situ Myosin Light Chain Kinase Activity is Upregulated in Fetal Compared with Adult Ovine Carotid Arteries (Elisha R. Injeti, Renan J. Sandoval, James M. Williams, et al.) American Journal of Physiology - Heart and Circulatory Physiology (2008)

Postnatal decreases in vascular reactivity involve decreases in the thick filament component of myofilament calcium sensitivity, which is measured as the relationship between cytosolic calcium concentration and myosin light chain (MLC20) phosphorylation. The present study ...

Postnatal Maturation Modulates Relationships Among Cytosolic Ca2+, Myosin Light Chain Phosphorylation, and Contractile Tone in Ovine Cerebral Arteries (Renan J. Sandoval, Elisha R. Injeti, William T. Gerthoffer, et al.) American Journal of Physiology - Heart and Circulatory Physiology (2007)

The present study tests the hypothesis that age-related changes in patterns of agonist-induced myofilament Ca2+ sensitization involve corresponding differences in the relative contributions of thick- and thin-filament regulation to overall myofilament Ca2+ sensitivity. Posterior communicating ...

Myogenic Contractility is More Dependent on Myofilament Calcium Sensitization in Term Fetal than Adult Ovine Cerebral Arteries (Renan J. Sandoval, Elisha R. Injeti, James M. Williams, et al.) American Journal of Physiology - Heart and Circulatory Physiology (2007)

Regulation of cytosolic calcium and myofilament calcium sensitivity varies considerably with postnatal age in cerebral arteries. Because these mechanisms also govern myogenic tone, the present study used graded stretch to examine the hypothesis that myogenic ...

Chronic Hypoxic Decreases in Soluble Guanylate Cyclase Protein and Enzyme Activity are Age Dependent in Fetal and Adult Ovine Carotid Arteries (James M. Williams, Charles R. White, Melody M. Chang, et al.) Journal of Applied Physiology (2006)

The present study tests the hypothesis that chronic hypoxia enhances reactivity to nitric oxide (NO) through age-dependent increases in soluble guanylate cyclase (sGC) and protein kinase G (PKG) activity. In term fetal and adult ovine ...

Influence of Quinidine, Selegiline and Amphotericin-B on the Pharmacokinetics and Pharmacodynamics of Tolbutamide in Rabbits (Sreemantula Satyanarayana, Yellela S.R. Krishnaiah, Kilari K. Eswar, et al.) Indian Drugs (1998)

Abstracts (10)

Chlorogenic Acid Increases Basal Tone with No Effect on Relaxation of Rat Ileal Smooth Muscles by Mechanisms Independent of PKG Mediated Effects on Myosin Light Chain Phosphorylation (Sarah Berman, Jamie Huston, Austin Lail, et al.) The FASEB Journal (2019)

Chlorogenic acid (CGA) is a dietary polyphenolic compound commonly present in coffee, fruits and vegetables. The pharmacological properties of CGA include antioxidant, antibacterial, anti-inflammatory, and antithrombotic effects. Previous experimental studies have shown that CGA induces ...

Development of a Method for Imaging Erythrocytes Using Atomic Force Microscope (Rebecca Widder, Xidong Chen and Elisha R. Injeti) Journal of Clinical Pharmacology in Drug Development (2012)

Statement of Purpose, Innovation or Hypothesis: Imaging living or fixed cells in their natural environment has been the focus of nano-biotechnology research involving Atomic Force Microscope (AFM). Because of its superior sensitivity in measuring molecular ...

Integrating Interprofessionalism in the Development of New School of Pharmacy at Cedarville University (Elisha R. Injeti, Douglas C. Anderson, Aleda M.H. Chen, et al.) American Journal of Pharmaceutical Education (2012)

Cedarville University has been offering undergraduate education in pre-pharmacy and nursing for more than 30 years. Current development of graduate and professional programs in health sciences began as a result of University's strategic plan. From ...

Validation of a Novel Sensor System for Real Time Monitoring of Urine Bag Fill Levels (Rebecca Widder, Anthony Boiarski, Ronald Wathen, et al.) American Journal of Pharmaceutical Education (2012)

Application of Atomic Force Microscope in Imaging Ciliary Structures of Tetrahymena Thermophilia (Kyong Ha Woo, Xidong Chen and Elisha R. Injeti) The Journal of Clinical Pharmacology (2011)

Statement of Purpose, Innovation or Hypothesis: Cilia are antenna-like structures that are considered as useless evolution-ary vestige, similar to tailbone. But recent research indicates that cilia are cellular organelles that have functional significance in maintaining ...

Rage Behavior in Developmentally Disabled Children May Be Due to Over-Activity of Immature Adrenergic System (Ralph Ankenman and Elisha R. Injeti) The Journal of Clinical Pharmacology (2010)

Psychotropic medications are one of the most widely prescribed medications in the United States. In recent times, the use of psychotropic medications among children especially those with developmental disabilities have increased significantly. Given this background, ...

Immature Beta-adrenergic Over- Activity Can Cause Rage Behavior in Children (Elisha R. Injeti and Ralph Ankenman) Proceedings of the American Scientific Affliliation (2010)

Unregulated Beta-adrenergic Over-activity May Be Involved in Rage Behavior of Developmentally Disabled Children (Ralph Ankenman and Elisha R. Injeti) Proceedings of the Ohio Pharmacists Association Annual Conference (2010)

Myosin Light Chain Kinase and Regulatory Myosin Light Chain Are More Tightly Co-localized in Fetal Compared to Adult Ovine Carotid Arteries (William J. Pearce, Elisha R. Injeti, Jenna M. Abrassart, et al.) The Journal of the Federation of American Societies for Experimental Biology (2009)

Postnatal Maturation Increases the Abundance, but Decreases the Specific Activity, of MLCK in Ovine Carotids (Elisha R. Injeti, Renan J. Sandoval, James M. Williams, et al.) The Journal of the Federation of American Societies for Experimental Biology (2007)

Research Poster Presentations (26)

Chlorogenic Acid Increases Basal Tone with No Effect on Relaxation of Rat Ileal Smooth Muscles by Mechanisms Independent of PKG Mediated Effects on Myosin Light Chain Phosphorylation (Sarah Berman, Jamie Huston, Austin Lail, et al.) Experimental Biology 2019 Annual Meeting (2019)

Chlorogenic acid (CGA) is a dietary polyphenolic compound commonly present in coffee, fruits and vegetables. The pharmacological properties of CGA include antioxidant, antibacterial, anti-inflammatory, and antithrombotic effects. Previous experimental studies have shown that CGA induces ...

The Effect of Andrographolide on the Metabolism of Carbamazepine in Rats (Elizabeth Aziz, Samuel Franklin, Ankit Pandav, et al.) The Research and Scholarship Symposium (2013-2019) (2016)

Objective: To determine if andrographolide (AND) impacts the pharmacokinetics of carbamazepine (CBZ). Background: CBZ is an anticonvulsant medication that is metabolized in the liver by cytochrome P450 (CYP) enzymes. AND is an over-the-counter medication that ...

Herb-Drug Interaction of Andrographolide on the Pharmacokinetics of Carbamazepine in Rats (Elizabeth Aziz, Samuel Franklin, Ankit Pandav, et al.) Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session (2015)

Objective: To determine if andrographolide (AND) impacts the pharmacokinetics of carbamazepine (CBZ). Background: CBZ is an anticonvulsant medication that is metabolized in the liver by cytochrome P450 (CYP) enzymes. AND is an over-the-counter medication that ...