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Varenicline for Smoking Cessation in Patients with Coronary Heart Disease
Clinical & Population Health Research
  • Ira S. Ockene, University of Massachusetts Medical School
  • Elena Salmoirago Blotcher, University of Massachusetts Medical School
Student Author(s)
Elena Salmoirago Blotcher
UMMS Affiliation
Clinical and Population Health Research Program; Department of Medicine, Division of Cardiovascular Medicine
Document Type
Medical Subject Headings
Benzazepines; Quinoxalines; Smoking Cessation; Cardiovascular Diseases
Despite the decline in cigarette smoking over the past 40 years, self-reported data from the National Health Interview Survey show that 19.8% (43.4 million) of US adults were still smokers in 2007.1 Attempts to quit during the previous year in the general population decreased from 47% in 1993 to 38.8% in 2007, and only 4% to 7% of smokers trying to quit each year will eventually succeed. Cardiovascular diseases are the leading cause of death in Western countries, and cigarette smoking has a clear cause-and-effect relationship with atherosclerotic disease with the risk of myocardial infarction (MI) increasing with the number of cigarettes smoked. Similarly strong evidence indicates that smoking cessation alone can result in a 36% reduction in the crude relative risk of mortality in smokers who quit versus those who do not.5 The risk decreases rapidly: after only 1 year of cessation, quitters have a lower relative risk (RR=0.63) of death from coronary heart disease (CHD) than do nonquitters, which decreases even further (RR=0.38) after 3 years of cessation. Consequently, efforts to find effective treatments to enhance smoking cessation are of great importance.
Rights and Permissions
Citation: Ockene I, Salmoirago-Blotcher E. Varenicline for smoking cessation in patients with coronary heart disease. Circulation. Jan 19 2010;121(2):188-190.
Related Resources
Link to article in PubMed
PubMed ID
Citation Information
Ira S. Ockene and Elena Salmoirago Blotcher. "Varenicline for Smoking Cessation in Patients with Coronary Heart Disease" Vol. 121 Iss. 2 (2010) ISSN: 1524-4539
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