Immigrant parents may struggle to secure and maintain employment if they raise children with disabilities. The current study examines data from immigrant parents responding to the 2018 National Survey of Children’s Health, including 618 raising children with special health care needs (CSHCN) and 2937 parenting children needing typical care. Parents of CSHCN had higher levels of both aggravation and resilience, but less access to a medical home than parents with typical care responsibilities. Immigrants were less likely to change jobs, but more likely to cut back work hours, or quit work, if they had CSHCNs lacking a medical home, missing more school days, and living in unsafe neighborhoods. Parents of CHSHNs also spent substantial time coordinating care and providing health care at home. Results indicate the need for service providers to connect immigrant families with CSHCNs with culturally supportive organizations that can help them handle family responsibilities while maintaining employment.