Skip to main content
Real-Time Mobile Detection of Drug Use with Wearable Biosensors: A Pilot Study
Preventive and Behavioral Medicine Publications and Presentations
  • Stephanie Carreiro, University of Massachusetts Medical School
  • David A. Smelson, University of Massachusetts Medical School
  • Megan Ranney, Warren Alpert Brown Medical School
  • Keith J. Horvath, University of Minnesota - Twin Cities
  • Rosalind W. Picard, Massachusetts Institute of Technology
  • Edwin D. Boudreaux, University of Massachusetts Medical School
  • Rashelle B. Hayes, University of Massachusetts Medical School
  • Edward W. Boyer, University of Massachusetts Medical School
UMMS Affiliation
Department of Emergency Medicine; Department of Psychiatry; Department of Medicine, Division of Preventive and Behavioral Medicine
Document Type
While reliable detection of illicit drug use is paramount to the field of addiction, current methods involving self-report and urine drug screens have substantial limitations that hinder their utility. Wearable biosensors may fill a void by providing valuable objective data regarding the timing and contexts of drug use. This is a preliminary observational study of four emergency department patients receiving parenteral opioids and one individual using cocaine in a natural environment. A portable biosensor was placed on the inner wrist of each subject, to continuously measure electrodermal activity (EDA), skin temperature, and acceleration. Data were continuously recorded for at least 5 min prior to drug administration, during administration, and for at least 30 min afterward. Overall trends in biophysiometric parameters were assessed. Injection of opioids and cocaine use were associated with rises in EDA. Cocaine injection was also associated with a decrease in skin temperature. Opioid tolerance appeared to be associated with a blunted physiologic response as measured by the biosensor. Laterality may be an important factor, as magnitude of response varied between dominant and nondominant wrists in a single patient with bilateral wrist measurements. Changes in EDA and skin temperature are temporally associated with intravenous administration of opioids and cocaine; the intensity of response, however, may vary depending on history and extent of prior use.
Rights and Permissions
Citation: J Med Toxicol. 2014 Oct 21. doi:10.1007/s13181-014-0439-7 [Epub ahead of print] Link to article on publisher's site.
Related Resources
Link to Article in PubMed
  • Biosensor,
  • Drug testing,
  • MHealth,
  • Drug abuse,
  • Electrodermal activity
PubMed ID
Citation Information
Stephanie Carreiro, David A. Smelson, Megan Ranney, Keith J. Horvath, et al.. "Real-Time Mobile Detection of Drug Use with Wearable Biosensors: A Pilot Study" (2014) ISSN: 1556-9039 (Linking)
Available at: