Time Interval From Conservative Breast Surgery To Breast Irradiation In Early Stage Node Negative Breast Cancer: 17-Year Follow-Up Results And Patterns Of RecurrenceInt J Radiation Oncol Biol Phys (2015)
AbstractPurpose: A retrospective chart review was conducted to determine if the time interval from conservative breast surgery to breast irradiation (surgery – radiotherapy interval) in early stage node negative breast cancer had any detrimental effect on recurrence rates. Materials and Methods: There were 566 patients with T1-T3, N0 breast cancer treated with breast conserving surgery and breast irradiation and without adjuvant systemic treatment between 1985 and 1992. The surgery – radiotherapy intervals used for analysis were: 0-8 weeks (201 patients), >8-12 weeks (233 patients), >12-16 weeks (91 patients) and >16 weeks (41 patients). Kaplan-Meir estimates of time to local-recurrence, disease-free survival, distant-free survival, cause-specific survival and overall survival rates were calculated. Results: Median follow-up was 17.4 years. Patients in all 4 time intervals were similar in terms of patient characteristics and pathologic features. There was no statistically significant difference between the 4 time groups in local-recurrence (p=0.67) or disease-free survival (p=0.45). The local recurrence rate at 5, 10 and 15 years was 4.9%, 11.5% and 15.0% respectively. The distant-disease relapse rate at 5, 10 and 15 years was 10.6%, 15.4% and 18.5% respectively. The disease-free failure rate at 5, 10 and 15 years was 20%, 32.3% and 39.8% respectively. Cause-specific survival at 5, 10 and 15 years was 92%, 84.6 % and 79.8% respectively. The overall survival at 5, 10 and 15 years was 89.3%, 79.2% and 66.9%. Conclusion: Surgery-radiotherapy intervals up to 16 weeks from definitive breast surgery are not associated with any increased risk of recurrence in early stage node negative breast cancer. There is a steady local recurrence rate of 1% per year with adjuvant radiation alone.
- 17-year radiation wait time results
Publication DateWinter February, 2015
Citation InformationOlga Vujovic, Edward Yu, Anil Cherian, Rashid Dar, et al.. "Time Interval From Conservative Breast Surgery To Breast Irradiation In Early Stage Node Negative Breast Cancer: 17-Year Follow-Up Results And Patterns Of Recurrence" Int J Radiation Oncol Biol Phys Vol. 91 Iss. 2 (2015)
Available at: http://works.bepress.com/edwardyu/94/