Background The objective of this study was to investigate risk factors associated with persistent or recurrent upper extremity and neck pain among engineering graduate students. Methods A random sample of 206 Electrical Engineering and Computer Science (EECS) graduate students at a large public university completed an online questionnaire. Results Approximately 60% of respondents reported upper extremity or neck pain attributed to computer use and reported a mean pain severity score of 4.5 (±2.2; scale 0–10). In a final logistic regression model, female gender, years of computer use, and hours of computer use per week were significantly associated with pain. Conclusions The high prevalence of upper extremity pain reported by graduate students suggests a public health need to identify interventions that will reduce symptom severity and prevent impairment. Am. J. Ind. Med. 46:297–303, 2004. © 2004 Wiley-Liss, Inc.