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Effects of Cardiorespiratory Fitness on Serum Ferritin Concentration and Incidence of Type 2 Diabetes: Evidence from Aerobics Center Longitudinal Study (ACLS)
Review of Diabetes Studies (2008)
  • Tuan Le
  • Chiehwen Ed Hsu
Abstract
Background: Several studies found that cardiorespiratory fitness (CRF) and physical activity (PA) are inversely associated with type 2 diabetes mellitus (T2DM). They both play an important role in reducing serum ferritin (SF) concentration. Increased SF concentration is considered a contributing factor for developing T2DM. Methods: The present cohort study investigated 5,512 adult participants enrolled in the Aerobics Center Longitudinal Study (ACLS) between 1995 and 2001. The subjects completed a comprehensive medical examination and a SF evaluation, and had been followed up until either diabetes onset, death, or the cut-off date of November 2007. Three CRF levels were categorized by sex-age specific group. SF quartile levels were defined by sex and menopausal status. Incidence of T2DM were calculated for 10,000 person-years, and hazard ratios (HR) were computed with 95% confidence interval to predict the incidence of T2DM based on SF quartiles and CRF levels. Results: SF concentration was significantly higher in males than in females [148.5 (± 104.7) ng/ml versus 52.2 (± 45.9) ng/ml, respectively] and was inversely associated with CRF levels. Among the high CRF group, 32.7 % of participants had a low SF concentration whereas only 16.8% of participants had a high SF concentration level. After adjusting for possible confounders, male participants in the highest SF quartile level had 1.7 times (HR: 1.67, 95% CI: 1.05, 2.66; p-trend= 0.027) increased risk for developing T2DM as compared to those in the lowest SF quartile group. For males, incidence of new-onset diabetes cases increased significantly across the SF quartiles from 72.4 (SF quartile I) to 148.2 (SF quartile IV). However, the association did not hold true for females. Conclusion: Lower SF concentration was associated with lower risk of developing T2DM in those participating in CRF. The findings suggested that clinicians should measure SF in routine medical check-ups for those patients at higher risk for developing T2DM and should use SF concentration as a diabetic predictor. Therefore, clinicians and public health professionals should promote regular physical activity or fitness to reduce incidence of T2DM and other chronic diseases.
Keywords
  • Diabetes,
  • metabolism diseases
Publication Date
Fall December, 2008
Citation Information
Tuan Le and Chiehwen Ed Hsu. "Effects of Cardiorespiratory Fitness on Serum Ferritin Concentration and Incidence of Type 2 Diabetes: Evidence from Aerobics Center Longitudinal Study (ACLS)" Review of Diabetes Studies Vol. 5 Iss. 4 (2008)
Available at: http://works.bepress.com/edhsu/50/