Article
Hybrid Nanoreactors: Coupling Enzymes and Small-Molecule Catalysts within Virus-Like Particles
Israel Journal of Chemistry
(2015)
Abstract
Virus-like particles (VLPs) provide unique scaffolds for the construction of coupled catalytic systems by attachment and encapsulation of catalysts within their hollow interiors. The interior of VLPs provides an environment where catalysts of biological or synthetic origins can be confined, protected, and colocalized in close proximity with catalysts of different types. Herein, we utilize the P22VLP as a scaffold to construct a synthetic hybrid catalyst by attachment of a small organometallic catalyst to the interior colocalized with an encapsulated enzyme. This produces a complex and active coupled biomimetic catalyst system. By combining both enzymatic and synthetic catalysts together, new biologicalsynthetic hybrid materials can be produced that incorporate the best of both catalytic systems.
Keywords
- enzyme catalysis,
- metalloenzymes,
- nanoparticles,
- nanotechnology,
- viruses
Disciplines
Publication Date
January, 2015
DOI
10.1002/ijch.201400092
Publisher Statement
First published in Israel Journal of Chemistry.
Citation Information
Patterson, D. P. (2015). Hybrid Nanoreactors: Coupling Enzymes and Small-Molecule Catalysts within Virus-Like Particles. Israel Journal of Chemistry.