|Present||Assistant Professor, University of Texas at Tyler ‐ Chemistry & Biochemistry|
Honors and Awards
- Outstanding Senior in Chemistry, Bowling Green State University - 2005
- NIH Chemical Biology Interface Training Program Fellowship, National Institute of Health/University of Michigan - 2006
- NIH Chemical Biology Interface Training Program Fellowship, National Institute of Health/University of Michigan - 2007
- NIH Chemical Biology Interface Training Program Fellowship, National Institute of Health/University of Michigan - 2008
- Department of Chemistry Dissertation Fellowship, University of Michigan - 2010
- Undergraduate Faculty Research Award, The Department of Chemistry & Biochemistry, University of Texas at Tyler - 2015
- CHEM 1105: Introductory Chemistry I Laboratory
- CHEM 1111: General Chemistry I Laboratory
- CHEM 4135: Biochemistry I Laboratory
- CHEM 4334: Biochemistry I
|2011||Ph.D., University of Michigan ‐ Chemistry|
|2005||B.S., Bowling Green State University ‐ Chemistry|
Research Works (14)
Self-assembling biomolecular catalysts for hydrogen production Nature Chemistry (2015)
The chemistry of highly evolved protein-based compartments has inspired the design of new catalytically active materials that self-assemble from biological components. A frontier of this biodesign is the potential to contribute new catalytic systems for ...
Design of a VLP-nanovehicle for CYP450 enzymatic activity delivery Journal of Nanobiotechnology (2015)
BackgroundThe intracellular delivery of enzymes for therapeutic use has a promising future for the treatment of several diseases such as genetic disorders and cancer. Virus-like particles offer an interesting platform for enzymatic delivery to targeted ...
Hybrid Nanoreactors: Coupling Enzymes and Small-Molecule Catalysts within Virus-Like Particles Israel Journal of Chemistry (2015)
Virus-like particles (VLPs) provide unique scaffolds for the construction of coupled catalytic systems by attachment and encapsulation of catalysts within their hollow interiors. The interior of VLPs provides an environment where catalysts of biological or ...
Characterization of a highly flexible self-assembling protein system designed to form nanocages Protein Science (2014)
The design of proteins that self-assemble into well-defined, higher order structures is an important goal that has potential applications in synthetic biology, materials science, and medicine. We previously designed a two-component protein system, designated A-(+) ...
Constructing catalytic antimicrobial nanoparticles by encapsulation of hydrogen peroxide producing enzyme inside the P22 VLP Journal of Materials Chemistry B (2014)
Here we examine a self-assembling virus like particle to construct catalytically active nanoparticles that can inhibit bacterial growth. The results suggest that encapsulation of enzymes inside VLPs can be exploited to develop new bionanomaterials with ...
Encapsulation of an Enzyme Cascade within the Bacteriophage P22 Virus-Like Particle ACS Chemical Biology (2014)
Developing methods for investigating coupled enzyme systems under conditions that mimic the cellular environment remains a significant challenge. Here we describe a biomimetic approach for constructing densely packed and confined multienzyme systems through the co-encapsulation ...
Virus-like particles as antigenic nanomaterials for inducing protective immune responses in the lung Nanomedicine (2014)
The lung is a major entry point for many of the most detrimental pathogens to human health. The onslaught of pathogens encountered by the lung is counteracted by protective immune responses that are generated locally, ...
Rescuing recombinant proteins by sequestration into the P22 VLP Chemical Communications (2013)
Here we report the use of a self-assembling protein cage to sequester and solubilize recombinant proteins which are usually trafficked to insoluble inclusion bodies. Our results suggest that protein cages can be used as novel ...
Biomimetic Antigenic Nanoparticles Elicit Controlled Protective Immune Response to Influenza ACS Nano (2013)
Here we present a biomimetic strategy toward nanoparticle design for controlled immune response through encapsulation of conserved internal influenza proteins on the interior of virus-like particles (VLPs) to direct CD8+ cytotoxic T cell protection. Programmed encapsulation ...
Nanoreactors by Programmed Enzyme Encapsulation Inside the Capsid of the Bacteriophage P22 ACS Nano (2012)
The virus like particle (VLP) derived from bacteriophage P22 presents a unique platform for constructing catalytically functional nanomaterials by encapsulation of enzymes into its interior. Encapsulation has been engineered to be genetically programmed allowing “one ...
Virus-like particle nanoreactors: programmed encapsulation of the thermostable CelB glycosidase inside the P22 capsid Soft Matter (2012)
Self-assembling biological systems hold great potential for the synthetic construction of new active soft nanomaterials. Here we demonstrate the hierarchical bottom-up assembly of bacteriophage P22 virus-like particles (VLPs) that encapsulate the thermostable CelB glycosidase creating ...
Evaluation of a symmetry-based strategy for assembling protein complexes RSC Advances (2011)
We evaluate a strategy for assembling proteins into large cage-like structures, based on the symmetry associated with the native protein's quaternary structure. Using a trimeric protein, KDPG aldolase, as a building block, two fusion proteins ...