Skip to main content
Article
Cytomegalovirus Reactivation after Bendamustine-Based Chemotherapy: A Case Report
All Scholarly Works
  • Abhimanyu Aggarwal, MD
  • Anthony Cretara, MD, Baystate Health
  • Katya Ford, MD, Baystate Health
  • Richard Steingart, MD, Baystate Health
  • Durane Walker, MD, Baystate Health
Document Type
Article, Peer-reviewed
Publication Date
9-1-2021
Abstract

Cytomegalovirus (CMV) is a DNA hepadnavirus, commonly implicated in reactivation disease after immunosuppression, especially in solid-organ and stem cell transplant patients. Bendamustine is an alkylating chemotherapeutic agent introduced into the management of hematological malignancies within the last decade. Few reports have raised potential concern for CMV reactivation disease after bendamustine therapy involving, but not limited to, the gastrointestinal tract, lungs, retina, and viremia. Cytomegalovirus reactivation in such instances should be added to the differential diagnoses for febrile nonneutropenic immunocompromised patients. Here, we report a case of an elderly gentleman recently diagnosed with mantle cell lymphoma who was started on chemotherapy with rituximab, bendamustine, and dexamethasone and developed CMV colitis and viremia after just 2 cycles of chemotherapy. © 2021 Wolters Kluwer Health, Inc. All rights reserved. Author keywords bendamustine; cytomegalovirus; cytomegalovirus disease; cytomegalovirus reactivation

Citation Information
Aggarwal, A., Cretara, A., Ford, K., Steingart, R., & Walker, D. (2021). Cytomegalovirus reactivation after bendamustine-based chemotherapy: A case report. Infectious Diseases in Clinical Practice, 29(5), E317-E320.