Over the past 12 years, 31 states have implemented a wide variety of policies to curb methamphetamine production in small toxic labs. This qualitative study explores the perceived impact of methamphetamine precursor laws in five states. Researchers conducted individual and focus group interviews with 77 key state policy makers and law enforcement personnel. Themes included barriers to development, perceived effectiveness and impact, effective provisions, and unintended consequences. Researchers suggest policy recommendations in light of renewed calls by policy makers and law enforcement personnel to address the recent rapid rise in small toxic lab seizures.