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Article
Label‐Free Microcavity Biosensors: Steps toward Facilitate Personalized Medicine
Sensors (2012)
  • Dragos Amarie, Indiana University - Bloomington
  • James A. Glazier, Indiana University - Bloomington
Abstract
Personalized medicine has the potential to improve our ability to maintain health and treat disease, while ameliorating continuously rising healthcare costs. Translation of basic research findings to clinical applications within regulatory compliance is required for personalized medicine to become the new foundation for practice of medicine. Deploying even a few of the thousands of potential diagnostic biomarkers identified each year as part of personalized treatment workflows requires clinically efficient biosensor technologies to monitor multiple biomarkers in patients in real time. This paper discusses a critical component of a regulatory system, a microcavity optical biosensor for label-free monitoring of biomolecular interactions at physiologically-relevant concentrations. While most current biosensor research focuses on improving sensitivity, this paper emphasizes other characteristics a biosensor technology requires to be practical in a clinical setting, presenting robust microcavity biosensors which are easy to manufacture and integrate with microfluidics into flexible and redesignable platforms making the microcavity biosensors deployable for continuous monitoring of biomarkers in body fluids in the clinic,  in dense 2D random arrays for high-throughput applications like drug-library screening in interactomics, and of the secretory behavior of single cells in the laboratory.
Keywords
  • Biosensors,
  • Microsensors,
  • Microcavity surface plasmon resonance,
  • Proteomics,
  • Interactomics,
  • Microfluidics,
  • Biomarkers,
  • Single cell secretion,
  • Personalized medicine
Disciplines
Publication Date
December 13, 2012
DOI
10.3390/s121217262
Publisher Statement
This is an open access article distributed under theCreative Commons Attribution License (CC BY)which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Article obtained fromSensors
Citation Information
Dragos Amarie and James A. Glazier. "Label‐Free Microcavity Biosensors: Steps toward Facilitate Personalized Medicine" Sensors Vol. 12 (2012) p. 17262 - 17294
doi:10.3390/s121217262
Available at: http://works.bepress.com/dragos-amarie/3/