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Effect of Sodium Selenite and Vitamin E on the Renal Cortex in Rats An Ultrastructure Study.pdf
Tissue Cell. (2014)
  • Hesham N Mustafa
  • Adel M Hussein
  • Hamed A Saleh
Abstract
This study examined the use of vitamin E to alleviate toxic effects of sodium selenite. Adult male albino rats (n=50) was divided into five groups. Group 1 was control, Groups 2 and 4 were treated with sodium selenite (2 mg/kg) for 2 and 4 weeks, respectively, Groups 3 and 5 were treated with sodium selenite (2 mg/kg) and vitamin E (100 mg/kg) for 2 and 4 weeks, respectively. Renal tissues were studied using anti-BCL2 and examined ultrastructurally. Positive Bax immunoreactivity was detected after 2 and more positive after 4 weeks and nearly all groups improved with co-administration of vitamin E. Ultrastructural study revealed lesions in Bowman's capsule and proximal convoluted tubules. The submicroscopic study revealed damage and necrosis of cortical structures after 2 and 4 weeks, respectively. After 4 weeks, cellular changes were seen, such as vacuolation and moderate degeneration of cells, widening of the urinary space scattered through the cortex with loss of cellular details, formation of apical buds, degeneration, and cellular rupture. Present findings disclosed an ameliorative effect of adding vitamin E to sodium selenite-induced changes in cortical tissues. Clinically, it is advised to add vitamin E to avoid selenium overdose hazards.
Keywords
  • Bax protein,
  • Sodium selenite,
  • Ultrastructure,
  • Vitamin E
Disciplines
Publication Date
Winter June 1, 2014
DOI
10.1016/j.tice.2014.03.002.
Citation Information
Hesham N Mustafa, Adel M Hussein and Hamed A Saleh. "Effect of Sodium Selenite and Vitamin E on the Renal Cortex in Rats An Ultrastructure Study.pdf" Tissue Cell. Vol. 46 Iss. 3 (2014) p. 170 - 177 ISSN: 0040-8166
Available at: http://works.bepress.com/dr_hesham_mustafa/6/