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Ameliorative potentials of a combination of Fenugreek and α-tocopherol on cadmium induced testicular toxicity An ultrastructural study (Manuscript).pdf
Folia Morphol (Warsz). (2015)
  • Hesham N Mustafa
  • Adel M Hussein
  • Mohamed H Badawoud
Abstract
BACKGROUND:
The current study aimed to elucidate the protective role of combined fenugreek and a-tocopherol against cadmium induced histopathological changes in the testes.
MATERIALS AND METHODS:
Thirty adult male albino rats divided into three equal groups 10 rats each. Group I is the control group. Group II received 5 mg/kg/ day cadmium chloride. Group III received 5 mg/kg/day cadmium chloride and 150 mg/kg/day fenugreek and 100 mg/kg/day of a-tocopherol. The treatment of all groups was done by oral gavage for 60 consecutive days. The testes were removed and subjected to histopathological and ultrastructure study.
RESULTS:
Rats exposed to cadmium showed severe histopathological changes in the testicular spermatogenic series, many vacuoles and multinucleated giant cells. Treatment with fenugreek and a-tocopherol partially improved the morphological changes, reduced tissue damage and rebuilt of the spermatogonia layer.
CONCLUSIONS:
Fenugreek and a-tocopherol might represent a promising medicinal combination to ameliorate the toxic effects of cadmium exposure.
Keywords
  • a-tocopherol,
  • cadmium chloride,
  • fenugreek,
  • seminiferous epithelium,
  • ultrastructure
Disciplines
Publication Date
Fall September 1, 2015
DOI
10.5603/FM.2015.0049.
Citation Information
Hesham N Mustafa, Adel M Hussein and Mohamed H Badawoud. "Ameliorative potentials of a combination of Fenugreek and α-tocopherol on cadmium induced testicular toxicity An ultrastructural study (Manuscript).pdf" Folia Morphol (Warsz). Vol. 74 Iss. 3 (2015) p. 325 - 334 ISSN: 0015-5659
Available at: http://works.bepress.com/dr_hesham_mustafa/5/