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Prophylactic role of coenzyme Q10 and Cynara scolymus L on doxorubicin-induced toxicity in rats.pdf
Indian Journal of Pharmacology (2015)
  • Hesham N Mustafa
  • Sally A El Awdan
  • Gehan A Hegazy
  • Gehad A Abdel Jaleel
Objective: The study aims to evaluate the protective effects of coenzyme Q10 (CoQ10) and Cynara scolymus L (CS) on doxorubicin (dox)-induced toxicity.
Materials and Methods: Sixty male rats were divided into six groups. Group 1 as a control. Group 2 received dox (10 mg/kg) intraperitoneally. Group 3 received CoQ10 (200 mg/kg). Group 4 received CS (500 mg/kg). Group 5 received CoQ10 (200 mg/kg) and dox (10 mg/kg). Group 6 received CS (500 mg/kg) and dox (10 mg/kg). The rats were then evaluated biochemically and immunohistochemically.
Results: Dox produced a significant deterioration of hepatic and renal functional parameters. Moreover, an upsurge of oxidative stress and nitrosative stress markers. The expression of alpha-smooth muscle actin (α-SMA) was increased and proliferating cell nuclear antigen (PCNA) expression was decreased. Administration of CoQ10 and CS resulted in a significant improvement of hepatic and renal functional parameters, and an improvement of both α-SMA and PCNA.
Conclusion: It is concluded that pretreatment with CoQ10 and CS is associated with up-regulation of favorable protective enzymes and down-regulation of oxidative stress. That can be advised as a supplement to dox-treated patients.
  • Alpha-smooth muscle actin,
  • doxorubicin,
  • nitrosative,
  • oxidative,
  • proliferating cell nuclear antigen
Publication Date
Winter November 17, 2015
Citation Information
Hesham N Mustafa, Sally A El Awdan, Gehan A Hegazy and Gehad A Abdel Jaleel. "Prophylactic role of coenzyme Q10 and Cynara scolymus L on doxorubicin-induced toxicity in rats.pdf" Indian Journal of Pharmacology Vol. 47 Iss. 6 (2015) p. 649 - 656 ISSN: 0253-7613
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