Skip to main content
CT Perfusion Imaging as an Early Biomarker of Differential Response to Stereotactic Radiosurgery in C6 Rat Gliomas
PLoS One
  • Timothy Pok Chi Yeung, Western University
  • Maher Kurdi
  • Yong Wang
  • Baraa Al-Khazraji
  • Laura Morrison
  • Lisa Hoffman
  • Dwayne Jackson
  • Cathie Crukley
  • Ting-Yim Lee
  • Glenn Bauman
  • Slav Yartsev
Document Type
Publication Date
URL with Digital Object Identifier
doi: 10.1371/journal.pone

BACKGROUND: The therapeutic efficacy of stereotactic radiosurgery for glioblastoma is not well understood, and there needs to be an effective biomarker to identify patients who might benefit from this treatment. This study investigated the efficacy of computed tomography (CT) perfusion imaging as an early imaging biomarker of response to stereotactic radiosurgery in a malignant rat glioma model.

METHODS: Rats with orthotopic C6 glioma tumors received either mock irradiation (controls, N = 8) or stereotactic radiosurgery (N = 25, 12 Gy in one fraction) delivered by Helical Tomotherapy. Twelve irradiated animals were sacrificed four days after stereotactic radiosurgery to assess acute CT perfusion and histological changes, and 13 irradiated animals were used to study survival. Irradiated animals with survival >15 days were designated as responders while those with survival ≤15 days were non-responders. Longitudinal CT perfusion imaging was performed at baseline and regularly for eight weeks post-baseline.

RESULTS: Early signs of radiation-induced injury were observed on histology. There was an overall survival benefit following stereotactic radiosurgery when compared to the controls (log-rank P

CONCLUSIONS: Response to stereotactic radiosurgery was heterogeneous, and early selection of responders and non-responders was possible using CT perfusion imaging. Validation of CT perfusion indices for response assessment is necessary before clinical implementation.

PMID: 25329655
Citation Information
Timothy Pok Chi Yeung, Maher Kurdi, Yong Wang, Baraa Al-Khazraji, et al.. "CT Perfusion Imaging as an Early Biomarker of Differential Response to Stereotactic Radiosurgery in C6 Rat Gliomas" PLoS One Vol. 9 Iss. 10 (2014) p. 109781
Available at: