Department of Psychiatry; Shriver Center; Center for Health Policy and Research; Intellectual and Developmental Disabilities Research Center
Adult; African Americans; Cocaine-Related Disorders; Cues; Feasibility Studies; Genotype; Humans; Logistic Models; Male; *Polymorphism, Single Nucleotide; Receptors, GABA-A; Receptors, Opioid, mu; Synaptic Transmission
BACKGROUND: This pilot feasibility study examined the role of genetics in laboratory-induced cocaine craving.
METHODS: Thirty-four African American, cocaine-depend- ent male subjects underwent a baseline assessment, cue-exposure session, and genetic analysis. Subjects were classified as either cue-reactive or nonreactive.
RESULTS: Among single nucleotide polymorphism markers in 13 candidate genes examined for association with cocaine cue-reactivity, two were statistically significant: GABRA2 (coding for GABA-A receptor alpha-2 subunit; rs11503014, nominal p= .001) and OPRM1 (coding for mu opioid receptor; rs2236256, nominal p= .03).
CONCLUSIONS: These pilot results suggest that cocaine craving shows variability among cocaine-dependent subjects, and that GABRA2 and OPRM1 polymorphisms have differential influences on cocaine cue-reactivity, warranting studies in future research.
DOI of Published Version
Smelson D, Yu L, Buyske S, Gonzalez G, Tischfield J, Deutsch CK, Ziedonis D.
Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with
cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission
involvement in cocaine dependence. Am J Addict. 2012 Sep-Oct;21(5):411-5. doi:
10.1111/j.1521-0391.2012.00253.x. PubMed PMID: 22882391; PubMed Central PMCID:
Link to article on publisher's site
David A. Smelson, Lei Yu, Steven Buyske, Gerardo Gonzalez, et al.. "Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence" Vol. 21 Iss. 5 (2012) ISSN: 1055-0496 (Linking)
Available at: http://works.bepress.com/douglas_ziedonis/108/