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Article
Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence
Center for Health Policy and Research (CHPR) Publications
  • David A. Smelson, University of Massachusetts Medical School
  • Lei Yu, Rutgers University
  • Steven Buyske, Rutgers University
  • Gerardo Gonzalez, University of Massachusetts Medical School
  • Jay Tischfield, Rutgers University
  • Curtis K. Deutsch, University of Massachusetts Medical School
  • Douglas M. Ziedonis, University of Massachusetts Medical School
UMMS Affiliation
Department of Psychiatry; Shriver Center; Center for Health Policy and Research; Intellectual and Developmental Disabilities Research Center
Date
9-1-2012
Document Type
Article
Medical Subject Headings
Adult; African Americans; Cocaine-Related Disorders; Cues; Feasibility Studies; Genotype; Humans; Logistic Models; Male; *Polymorphism, Single Nucleotide; Receptors, GABA-A; Receptors, Opioid, mu; Synaptic Transmission
Abstract
BACKGROUND: This pilot feasibility study examined the role of genetics in laboratory-induced cocaine craving. METHODS: Thirty-four African American, cocaine-depend- ent male subjects underwent a baseline assessment, cue-exposure session, and genetic analysis. Subjects were classified as either cue-reactive or nonreactive. RESULTS: Among single nucleotide polymorphism markers in 13 candidate genes examined for association with cocaine cue-reactivity, two were statistically significant: GABRA2 (coding for GABA-A receptor alpha-2 subunit; rs11503014, nominal p= .001) and OPRM1 (coding for mu opioid receptor; rs2236256, nominal p= .03). CONCLUSIONS: These pilot results suggest that cocaine craving shows variability among cocaine-dependent subjects, and that GABRA2 and OPRM1 polymorphisms have differential influences on cocaine cue-reactivity, warranting studies in future research.
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Citation: Smelson D, Yu L, Buyske S, Gonzalez G, Tischfield J, Deutsch CK, Ziedonis D. Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence. Am J Addict. 2012 Sep-Oct;21(5):411-5. doi: 10.1111/j.1521-0391.2012.00253.x. PubMed PMID: 22882391; PubMed Central PMCID: PMC3425941. Link to article on publisher's site
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Link to Article in PubMed
Citation Information
David A. Smelson, Lei Yu, Steven Buyske, Gerardo Gonzalez, et al.. "Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence" Vol. 21 Iss. 5 (2012) ISSN: 1055-0496 (Linking)
Available at: http://works.bepress.com/douglas_ziedonis/108/