Article
Insulin-Like Growth-Factor Binding Protein (IGFBP) Serum Levels and Hepatic IGFBP-2 and -3 mRNA Expression in Diabetic and Insulin-Treated Swine (Sus scrofa)
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry
Document Type
Article
Publication Date
10-1-1993
Disciplines
Abstract
1. Diabetes had no significant effect on IGFBP-3 message and serum levels however, subsequent insulin treatment caused more than a two-fold increase in both hepatic IGFBP-3 mRNA and serum levels above controls (P < 0.05).
2. The induction of diabetes in pigs significantly increased the steady state levels of IGFBP-2 mRNA in the liver of young swine (P < 0.05).
3. Both liver message and serum IGFBP-2 were reduced to control levels with insulin therapy.
4. We report here that in addition to its affects on IGFBP-2, insulin is involved in the regulation of IGFBP-3 expression.
DOI
10.1016/0305-0491(93)90311-R
Citation Information
Michael E. White, Douglas W. Leaman, Timothy G. Ramsay, Kimberly A. Kampman, et al.. "Insulin-Like Growth-Factor Binding Protein (IGFBP) Serum Levels and Hepatic IGFBP-2 and -3 mRNA Expression in Diabetic and Insulin-Treated Swine (Sus scrofa)" Comparative Biochemistry and Physiology Part B: Comparative Biochemistry Vol. 106 Iss. 2 (1993) p. 341 - 347 ISSN: 0305-0491 Available at: http://works.bepress.com/douglas-leaman/50/